1-[(2R,4R)-4-amino-2-methyl-6-[(4-methylphenyl)methyl]-3,4-dihydro-2H-quinolin-1-yl]ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-[(2R,4R)-4-amino-2-methyl-6-[(4-methylphenyl)methyl]-3,4-dihydro-2H-quinolin-1-yl]ethanone
• 化学式: C₂₀H₂₄N₂O
• 分子量: 308.4
• InChiKey: SEXLWWSUTZFQKK-AUUYWEPGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• EP3038621A2
  申请人：——

  公开号：EP3038621A2

  公开（公告）日：2016-07-06
• [EN] COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR<br/>[FR] COMPOSÉS ET MATRICES POUR UNE UTILISATION DANS LA RÉPARATION ET LA CROISSANCE DES OS
  申请人：HUMAN BIOMOLECULAR RES INST

  公开号：WO2014146039A2

  公开（公告）日：2014-09-18

  Compositions of small molecules, matrices, and isolated cells including methods of preparation, and methods for differentiation, trans-differentiation, and proliferation of animal cells into the osteoblast cell lineage were described. Examples of osteogenic materials that were administered to cells or co-cultured with cells are represented by compounds of Formula II, IV, and VI independently or preferably in combination with a matrix to afford bone cells. Small molecule-stimulated cells were also combined with a matrix, placed with a cellular adhesive or material carrier and implanted to a site in an animal for bone repair. Matrix pretreated with compounds of Formula II, IV, and VI were also used to cause cells to migrate to the matrix that is of use for therapeutic purposes.