Sodium;5-nitroquinolin-8-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Sodium;5-nitroquinolin-8-ol
• 英文别名: sodium;5-nitroquinolin-8-ol
• 化学式: C9H6N2NaO3+
• 分子量: 213.14
• InChiKey: SIEWAAKCHILRTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.15
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• BASE ADDITION SALTS OF NITROXOLINE AND USES THEREOF
  申请人：ASIERIS PHARMACEUTICAL TECHNOLOGIES CO., LTD.

  公开号：US20160031819A1

  公开（公告）日：2016-02-04

  Novel base addition salts of nitroxoline with improved solubility and increased urine secretion under physiological conditions are described. Pharmaceutical compositions and methods of treatment using the pharmaceutical compositions are also described.

  本发明描述了一种改善溶解度和在生理条件下增加尿液分泌的硝氧氮化物的新型基础盐。还描述了制药组合物和使用制药组合物的治疗方法。
• US9758484B2
  申请人：——

  公开号：US9758484B2

  公开（公告）日：2017-09-12
• [EN] BASE ADDITION SALTS OF NITROXOLINE AND USES THEREOF<br/>[FR] SELS D'ADDITION DE BASE DE NITROXOLINE ET LEURS UTILISATIONS
  申请人：PAN KE

  公开号：WO2014145723A1

  公开（公告）日：2014-09-18

  Novel base addition salts of nitroxoline with improved solubility and increased urine secretion under physiological conditions are described. Pharmaceutical compositions and methods of treatment using the pharmaceutical compositions are also described. The present invention relates to novel base addition salts of nitroxoline having improved solubility and stability in aqueous solutions as compared to nitroxoline or other salts of nitroxoline. The present invention also relates to pharmaceutical compositions comprising the base addition salts of nitroxoline, and methods of treating or preventing diseases, disorders, and conditions using these pharmaceutical compositions.