(1E,4E)-1-(2-methoxyphenyl)-5-(2-methylphenyl)penta-1,4-dien-3-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (1E,4E)-1-(2-methoxyphenyl)-5-(2-methylphenyl)penta-1,4-dien-3-one
• 化学式: C₁₉H₁₈O₂
• 分子量: 278.3
• InChiKey: UOUULFOOPKESQW-PHEQNACWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• MTOR-independent activator of TFEB for autophagy enhancement and uses thereof
  申请人：Hong Kong Baptist University

  公开号：US20150250741A1

  公开（公告）日：2015-09-10

  The present invention relates to a composition comprising an autophagy enhancement compound. Small molecules that are able to enhance autophagy and lysosome biogenesis by activating the gene TFEB which can prevent the accumulation of toxic protein aggregates in treating neurodegenerative diseases are disclosed.
• THERAPEUTIC AGENTS FOR SKIN DISEASES AND CONDITIONS
  申请人：STC. UNM

  公开号：US20160287531A1

  公开（公告）日：2016-10-06

  The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans-stilbene or stilbene hybrid and at least one antibiotic.
• US8841326B2
  申请人：——

  公开号：US8841326B2

  公开（公告）日：2014-09-23
• US9351946B2
  申请人：——

  公开号：US9351946B2

  公开（公告）日：2016-05-31
• US9540299B2
  申请人：——

  公开号：US9540299B2

  公开（公告）日：2017-01-10