1-(7-chloro-2-phenylquinolin-4-yl)-N,N-diethylpiperidin-4-amine;dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(7-chloro-2-phenylquinolin-4-yl)-N,N-diethylpiperidin-4-amine;dihydrochloride
• 化学式: C24H30Cl3N3
• 分子量: 466.9
• InChiKey: IJWGAWUNLGAHKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.71
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  19.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Quinolines derivatives as novel anticancer agents
  申请人：GENOSCIENCE PHARMA

  公开号：US10179770B2

  公开（公告）日：2019-01-15

  The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and non-neoplastic diseases.

  本发明提供了喹啉衍生物、喹啉衍生物的制造、含有喹啉衍生物的药物组合物以及喹啉衍生物作为药物的用途。本发明的活性化合物可用于治疗增殖性肿瘤和非肿瘤疾病。
• QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS
  申请人：Genoscience Pharma SAS

  公开号：EP2976333A1

  公开（公告）日：2016-01-27
• [EN] QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS<br/>[FR] DÉRIVÉS DE QUINOLINES EN TANT QUE NOUVEAUX AGENTS ANTICANCÉREUX
  申请人：GENOSCIENCE PHARMA

  公开号：WO2014147611A1

  公开（公告）日：2014-09-25

  The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and nonneoplastic diseases.