2-cyclopropyl-6,8-difluoro-4-oxo-7-pyridin-4-yl-1H-quinoline-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-cyclopropyl-6,8-difluoro-4-oxo-7-pyridin-4-yl-1H-quinoline-3-carboxylic acid
• 化学式: C₁₈H₁₂F₂N₂O₃
• 分子量: 342.3
• InChiKey: LEFKKQQALMDNJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  79.3
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] MULTI-TIERED HIGH THROUGH-PUT SCREEN FOR COMPOUNDS EFFECTIVE AGAINST BACTERIAL BIOFILM AND COMPOUNDS EFFECTIVE FOR INHIBITING AND ERADICATING BACTERIAL BIOFILM<br/>[FR] CRIBLAGE À HAUT DÉBIT À MULTIPLES PALIERS POUR DES COMPOSÉS EFFICACES CONTRE UN BIOFILM BACTÉRIEN, ET COMPOSÉS EFFECTIVES POUR L'INHIBITION ET L'ÉRADICATION D'UN BIOFILM BACTÉRIEN
  申请人：UNIV CINCINNATI

  公开号：WO2014152895A1

  公开（公告）日：2014-09-25

  A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each tier includes three specific biological process assays. The tier levels are a primary screen, a confirmation screen, and a dose-response screen, and the biological process assays include assays for total bacterial growth, bacterial metabolic activity, and biofilm formation.