(1S,4S,7R,10S,13R,16S,17R)-17,24-dihydroxy-10-[(4-methoxyphenyl)methyl]-4,7,9,13,15,29-hexamethyl-22-oxa-3,6,9,12,15,29-hexazatetracyclo[14.12.2.218,21.123,27]tritriaconta-18,20,23,25,27(31),32-hexaene-2,5,8,11,14,30-hexone

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: (1S,4S,7R,10S,13R,16S,17R)-17,24-dihydroxy-10-[(4-methoxyphenyl)methyl]-4,7,9,13,15,29-hexamethyl-22-oxa-3,6,9,12,15,29-hexazatetracyclo[14.12.2.218,21.123,27]tritriaconta-18,20,23,25,27(31),32-hexaene-2,5,8,11,14,30-hexone
• 化学式: C₄₀H₄₈N₆O₁₀
• 分子量: 772.8
• InChiKey: TWOWSRSKGJSZHZ-IZUQMIDASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  56
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  207
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• CHEMICAL ENTITIES AND THERAPEUTIC USES THEREOF
  申请人：The Regents of the University of Colorado, a body corporate

  公开号：US20150343016A1

  公开（公告）日：2015-12-03

  The present invention describes the use of translation inhibitors for the treatment of cancer and other disorders. Described herein are translation-inhibiting compounds, and methods of using those compounds for the treatment of cancer and other disorders. In some aspects the compounds inhibit translation elongation at the ribosome. In some aspects the compounds are used alone or in combination with known therapies.

  本发明描述了使用翻译抑制剂治疗癌症和其他疾病的方法。在此所描述的是翻译抑制化合物，以及使用这些化合物治疗癌症和其他疾病的方法。在某些方面，这些化合物抑制核糖体上的翻译延伸。在某些方面，这些化合物单独或与已知的治疗方法联合使用。
• BOURVADIN DERIVATIVES AND THERAPEUTIC USES THEREOF
  申请人：SU Tin Tin

  公开号：US20150238562A1

  公开（公告）日：2015-08-27

  The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvardin analog or related compound, and methods for treating disorders including cancer. In some aspects the compounds inhibit translation elongation at the ribosome. The compounds are used in combination with radiation therapy or with known chemotherapeutic compositions.
• US9452215B2
  申请人：——

  公开号：US9452215B2

  公开（公告）日：2016-09-27