5-羟基磺胺二甲嘧啶 | 51395-19-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-羟基磺胺二甲嘧啶
• 中文别名: 氯化3-[(4-氨基-2-甲基嘧啶-5-基)甲基]-2,5-二(2-羟基乙基)-4-甲基-1,3-噻唑-3-正离子
• 英文名称: 5-Hydroxysulphadimidine
• 英文别名: N-(4,6-dimethyl-5-hydroxyl-2-pyrimidine)-4-aminobenzene sulfonamide；4-amino-N-(5-hydroxy-4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide；Benzenesulfonamide, 4-amino-N-(5-hydroxy-4,6-dimethyl-2-pyrimidinyl)-；4-amino-N-(5-hydroxy-4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
• CAS: 51395-19-8
• 化学式: C₁₂H₁₄N₄O₃S
• 分子量: 294.334
• InChiKey: KDJUDADCYOYHLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  磺胺二甲嘧啶 在 ferrous(II) sulfate heptahydrate 、 zinc(II) sulfate heptahydrate 、 potassium dihydrogenphosphate 、 一水合硫酸镁 、 copper(II) choride dihydrate 、 calcium(II) chloride dihydrate 、 manganese(II) chloride tetrahydrate 、 cobalt(II) chloride hexahydrate 、 sodium molybdate dihydrate 、 sodium acetate 、 硼酸 、 氯化铵 、 potassium iodide 、 corn starch 作用下， 以 水 为溶剂， 生成 2-氨基-4,6-二甲基嘧啶 、 5-溴-2-哌嗪基嘧啶 、 N-(4,6-dimethyl-2-pyrimidine)-4-N-(benzenesulfonamide)benzenesulfonamide 、 N-(4,6-dimethyl-2-pyrimidine)-4-N-(4,6-dimethylpyrimidine)benzenesulfonamide 、 2-amino-5-hydroxypyrimidine-4,6(1H,3H)-dione 、 5-羟基磺胺二甲嘧啶 、 对氨基苯磺酸
  参考文献：
  名称：

  The performance and degradation mechanism of sulfamethazine from wastewater using IFAS-MBR

  摘要：

  Sulfamethazine (SMZ) is an important sulfonamide antibiotic. Although the concentration in the environment is small, it is harmful. The drug residues can be transferred, transformed or accumulated, affecting the growth of animals and plants. In this study, the integrated fixed-film activated sludge membrane bioreactor (IFAS-MBR) were constructed to investigate the performance and degradation mechanism of SMZ. The addition of SMZ had a significant impact on the removal of the chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N). The optimal operating conditions were hydraulic retention time (HRT) at 10 h and solid retention time (SRT) at 80 d, respectively. On this basis, the effects of different SMZ concentrations on nutrient removal, degradation, and sludge characteristics were compared. The removal efficiency of SMZ increased with the increase of SMZ concentration. The maximum removal rate was as high as 87%. The SMZ dosage also had an obvious effect on sludge characteristics. As the SMZ concentration increased, the extracellular polymer substances (EPS) concentration and the membrane resistance both decreased, which were beneficial for the reduction of membrane fouling. Finally, seven kinds of SMZ biodegradation intermediates were identified, and the possible degradation pathways were speculated. The microbial community results showed that the microbial diversity and richness in the reactor decreased after adding SMZ to the influent. The relative abundance of Bacteroidetes, Actinobacteria, Saccharibacteria and Nitrospirae increased at the phylum level. Sphingobacteria and Betaproteobacteria became dominant species at the class level. The relative abundance of norankp-Saccharibacteria and Nitrospirae increased significantly, and norank-p-Saccharibacteria may be the dominant bacteria for SMZ degradation. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.cclet.2019.08.031

文献信息

• Photolysis and photocatalytic decomposition of sulfamethazine antibiotics in an aqueous solution with TiO₂
  作者：Tai-Wei Tzeng、Shan-Li Wang、Chiing-Chang Chen、Chen-Chung Tan、Yu-Ting Liu、Tsan-Yao Chen、Yu-Min Tzou、C.C. Chen、J. T. Hung

  DOI：10.1039/c6ra13435a

  日期：——

  concentrations in the solutions. The apparent rate constants of SMT photo-decomposition reactions, which were well described by the pseudo-first-order kinetic model, ranged from 0.24 to 1.61 h−1. The overall photo-decomposition efficiencies of 0.072 mM SMT were the highest at pH 5.5 with 0.5 g L−1 TiO2 due to the adsorption-induced photocatalytic decomposition of SMT on TiO2. However, the SMT photolysis occurred

  磺胺二甲嘧啶（SMT）的光分解涉及同时发生的光催化和光催化反应。通过TiO 2负载，溶液中pH和初始SMT浓度的影响，系统地考察了这两个反应对TiO 2整体SMT光分解和SMT光分解中间体的相对贡献。由伪一级动力学模型很好地描述的SMT光分解反应的表观速率常数为0.24至1.61h -1。在0.5 g L -1 TiO 2的pH 5.5下，0.072 mM SMT的总光解效率最高由于SMT在TiO 2上被吸附诱导的光催化分解。但是，SMT在pH 10时发生光解的速度更快。两种反应性空穴和羟基自由基同时参与了SMT的光催化分解，而后者主导了SMT在TiO 2上的氧化反应。。使用LC-MS确定了SMT光分解的八个中间体。他们的时间依赖性分布表明，SMT的光分解是由苯胺和二甲基嘧啶基部分的羟基化引发的，随后是SMT的S–N键断裂。我们的结果表明，具有二甲基嘧啶基的中间体对光分解具有很强的抵抗力，
• The performance and degradation mechanism of sulfamethazine from wastewater using IFAS-MBR
  作者：Huanhuan Hou、Liang Duan、Beihai Zhou、Yuan Tian、Jian Wei、Feng Qian

  DOI：10.1016/j.cclet.2019.08.031

  日期：2020.2

  Sulfamethazine (SMZ) is an important sulfonamide antibiotic. Although the concentration in the environment is small, it is harmful. The drug residues can be transferred, transformed or accumulated, affecting the growth of animals and plants. In this study, the integrated fixed-film activated sludge membrane bioreactor (IFAS-MBR) were constructed to investigate the performance and degradation mechanism of SMZ. The addition of SMZ had a significant impact on the removal of the chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N). The optimal operating conditions were hydraulic retention time (HRT) at 10 h and solid retention time (SRT) at 80 d, respectively. On this basis, the effects of different SMZ concentrations on nutrient removal, degradation, and sludge characteristics were compared. The removal efficiency of SMZ increased with the increase of SMZ concentration. The maximum removal rate was as high as 87%. The SMZ dosage also had an obvious effect on sludge characteristics. As the SMZ concentration increased, the extracellular polymer substances (EPS) concentration and the membrane resistance both decreased, which were beneficial for the reduction of membrane fouling. Finally, seven kinds of SMZ biodegradation intermediates were identified, and the possible degradation pathways were speculated. The microbial community results showed that the microbial diversity and richness in the reactor decreased after adding SMZ to the influent. The relative abundance of Bacteroidetes, Actinobacteria, Saccharibacteria and Nitrospirae increased at the phylum level. Sphingobacteria and Betaproteobacteria became dominant species at the class level. The relative abundance of norankp-Saccharibacteria and Nitrospirae increased significantly, and norank-p-Saccharibacteria may be the dominant bacteria for SMZ degradation. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.