2-Benzofurancarboxamide, N-(2-((3aS,4S,9bS)-8-cyano-1-formyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo(3,2-C)quinolin-4-yl)-2-methylpropyl)-4,6-difluoro- | 1414376-79-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-Benzofurancarboxamide, N-(2-((3aS,4S,9bS)-8-cyano-1-formyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo(3,2-C)quinolin-4-yl)-2-methylpropyl)-4,6-difluoro-
• 英文别名: N-[2-[(3aS,4S,9bS)-8-cyano-1-formyl-2,3,3a,4,5,9b-hexahydropyrrolo[3,2-c]quinolin-4-yl]-2-methylpropyl]-4,6-difluoro-1-benzofuran-2-carboxamide
• CAS: 1414376-79-6
• 化学式: C₂₆H₂₄F₂N₄O₃
• 分子量: 478.5
• InChiKey: NFUDYVGPEWZTDV-XRJVTAMDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  98.4
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• METHODS OF REDUCING MAMMOGRAPHIC BREAST DENSITY AND/OR BREAST CANCER RISK
  申请人：Havah Therapeutics Pty Ltd

  公开号：EP3209301A1

  公开（公告）日：2017-08-30
• [EN] METHODS OF REDUCING MAMMOGRAPHIC BREAST DENSITY AND/OR BREAST CANCER RISK<br/>[FR] PROCÉDÉS DE RÉDUCTION DE LA DENSITÉ MAMMAIRE À LA MAMMOGRAPHIE ET/OU DU RISQUE DE CANCER DU SEIN
  申请人：HAVAH THERAPEUTICS PTY LTD

  公开号：WO2017066827A1

  公开（公告）日：2017-04-27

  The present disclosure is directed to generally methods and/or compositions for treating mammographic breast density and/or breast stiffness in a patient in need thereof, such as a pre- menopausal, a peri-menopausal or a post-memopausal patient, comprising the admimstration of an effective amount of androgenic agent and an effective amount of an aromatase inhibitor. The present disclosure is also directed to methods and/or compositions for reducing breast pain. The present disclosure is also directed to method and/or compositions for reduing elasticity and/or decreasing mechano -transduction on the genome of breast cells. The present disclosure is also directed to methods and/or compositions for stabilizing and/or increasing the levels of androgen receptor expression in breast tissue.