4-hydroxymethyl-2,8-bis(trifluoromethyl)quinoline | 73241-14-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-hydroxymethyl-2,8-bis(trifluoromethyl)quinoline
• 英文别名: 2,8-bis(trifluoromethyl)-4-hydroxymethylquinoline；(2,8-Bis(trifluoromethyl)quinolin-4-yl)methanol；[2,8-bis(trifluoromethyl)quinolin-4-yl]methanol
• CAS: 73241-14-2
• 化学式: C₁₂H₇F₆NO
• 分子量: 295.184
• InChiKey: BWQUVOQHTSQBHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-carbomethoxy-2,8-bis(trifluoromethyl)quinoline 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 以95%的产率得到4-hydroxymethyl-2,8-bis(trifluoromethyl)quinoline
  参考文献：
  名称：

  PHOTOCHEMICAL REACTIVITY OF MEFLOQUINE, A NEW SYNTHETIC ANTIMALARIAL

  摘要：

  The photochemistry of mefloquine, an experimental antimalarial drug, has been examined with an eye towards understanding its comparatively low phototoxicity.

  DOI：

  10.1246/cl.1982.211

文献信息

• Compositions for the treatment of pancreatic cancer and uses thereof
  申请人：University of Florida Research Foundation, Incorporated

  公开号：US10835524B2

  公开（公告）日：2020-11-17

  The invention pertains to compositions comprising inhibitors of PI3K, AKT and/or mTOR, one or more 4-quinolinemethanols and a pharmaceutically acceptable excipient. These compositions can contain subtherapeutic amounts of each active ingredient (PI3K, AKT, mTOR, one or more 4-quinolinemethanols and various combinations thereof). The invention also provides a method of treating various forms of cancer, such as breast cancer, prostate cancer, multiple myeloma, hepatocyte carcinoma, brain cancer, lung cancer, non-small cell lung carcinoma, colorectal cancer, melanoma and/or pancreatic cancer.

  本发明涉及由 PI3K、AKT 和/或 mTOR 抑制剂、一种或多种 4-喹啉甲醇和药学上可接受的赋形剂组成的组合物。这些组合物可以包含亚治疗量的每种活性成分（PI3K、AKT、mTOR、一种或多种 4-喹啉甲醇及其各种组合）。本发明还提供了一种治疗各种形式癌症的方法，如乳腺癌、前列腺癌、多发性骨髓瘤、肝细胞癌、脑癌、肺癌、非小细胞肺癌、结直肠癌、黑色素瘤和/或胰腺癌。
• EPLING, G. A.;YOON, UNG, CHAN, CHEM. LETT., 1982, N 2, 211-214
  作者：EPLING, G. A.、YOON, UNG, CHAN

  DOI：——

  日期：——
• PHOTOCHEMICAL REACTIVITY OF MEFLOQUINE, A NEW SYNTHETIC ANTIMALARIAL
  作者：Gary A. Epling、Ung Chan Yoon

  DOI：10.1246/cl.1982.211

  日期：1982.2.5

  The photochemistry of mefloquine, an experimental antimalarial drug, has been examined with an eye towards understanding its comparatively low phototoxicity.