3-Methyllactose | 33336-09-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Methyllactose
• 英文别名: (2S,3R,4S,5R,6R)-2-[(2R,3S,4R,5R)-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 33336-09-3
• 化学式: C₁₃H₂₄O₁₁
• 分子量: 356.327
• InChiKey: FHNIYFZSHCGBPP-LTEQSDMASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  179
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  3-Methyllactose 在 α(1->4) galactosyltransferase α(1->4)galactosyltransferase from N. meningitidis 、 β(1->3)N-acetylgalactosaminyltransferase-WbgU fusion enzyme 、 GalE from Escherichia coli K₁₂ 、 manganese(ll) chloride 、 bovine serum albumin 作用下， 以 various solvent(s) 为溶剂， 反应 48.0h， 生成 methyl O-(2-acetamido-2-deoxy-β-D-galactopyranosyl)-(1-3)-O-α-D-galactopyranosyl-(1-4)-O-β-D-galactopyranosyl-(1-4)-β-D-glucopyranoside
  参考文献：
  名称：

  Efficient synthesis of globoside and isogloboside tetrasaccharides by using β(1→3) N-acetylgalactosaminyltransferase/UDP-N-acetylglucosamine C4 epimerase fusion protein

  摘要：

  构建了β(1→3)N-乙酰半乳糖胺基转移酶/UDP-N-乙酰葡萄糖胺C4差向异构酶融合蛋白，并将其用于耦合酶促反应，以相应的乳糖苷受体为原料合成了多种四糖和异四糖衍生物。

  DOI：

  10.1039/b300831b

文献信息

• Effect of temperature modulations on TEMPO-mediated regioselective oxidation of unprotected carbohydrates and nucleosides
  作者：Mahipal Yadav、Charles L. Liotta、Ramanarayanan Krishnamurthy

  DOI：10.1016/j.bmcl.2018.01.066

  日期：2018.9

  the efficiency of TEMPO-catalyzed oxidation by modulating the temperature of the reaction. Mono-, di-, and tri-saccharides are oxidized regioselectively in yields of 75 to 92%. The present method is simple to implement and is also applicable for selective oxidations of other mono- and poly-hydroxy compounds including unprotected and partially protected nucleosides.

  未受保护的和部分受保护的寡糖的区域选择性氧化是非常受欢迎的目标。本文中，我们报告了通过调节反应温度，TEMPO催化氧化效率的显着提高。单糖，二糖和三糖被区域选择性地氧化，产率为75％到92％。本方法易于实施，也可用于包括未保护的和部分保护的核苷在内的其他单羟基和多羟基化合物的选择性氧化。
• Immunomodulating Compositions and uses Therefor
  申请人：Ralph John Stephen

  公开号：US20070207161A1

  公开（公告）日：2007-09-06

  The present invention discloses immunomodulating compositions. More particularly, the present invention discloses compositions comprising an immune-modulating agent and a lectin-interactive agent, which are useful for stimulating and prolonging host immune cell responses. The compositions of the present invention are particularly useful in the treatment and/or prophylaxis of a range of conditions including pathogenic infections, autoimmune diseases, transplant rejection, graft versus host disease, allergies, inflammatory disease, as well as cancers and tumours.
• IMMUNOMODULATING COMPOSITIONS AND USES THEREFOR
  申请人：Ralph Stephen John

  公开号：US20150265701A1

  公开（公告）日：2015-09-24

  The present invention discloses immunomodulating compositions. More particularly, the present invention discloses compositions comprising an immune-modulating agent and a lectin-interactive agent, which are useful for stimulating and prolonging host immune cell responses. The compositions of the present invention are particularly useful in the treatment and/or prophylaxis of a range of conditions including pathogenic infections, autoimmune diseases, transplant rejection, graft versus host disease, allergies, inflammatory disease, as well as cancers and tumours.
• US9050352B2
  申请人：——

  公开号：US9050352B2

  公开（公告）日：2015-06-09
• US9770503B2
  申请人：——

  公开号：US9770503B2

  公开（公告）日：2017-09-26