dimethyl 2-(4-chlorobenzoyl)cyclopentane-1,1-dicarboxylate | 1567374-19-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dimethyl 2-(4-chlorobenzoyl)cyclopentane-1,1-dicarboxylate
• 英文别名: Dimethyl 2-(4-chlorobenzoyl)cyclopentane-1,1-dicarboxylate
• CAS: 1567374-19-9
• 化学式: C₁₆H₁₇ClO₅
• 分子量: 324.761
• InChiKey: UMXNYGMTGBRSTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-溴戊酰氯 在 sodium methylate 、 potassium iodide 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 dimethyl 2-(4-chlorobenzoyl)cyclopentane-1,1-dicarboxylate
  参考文献：
  名称：

  Anodic cyclization of dimethyl 2-(5-aryl-5-oxopentyl)malonates into the corresponding dimethyl 2-aroylcyclopentane-1,1-dicarboxylates

  摘要：

  A wide range of dimethyl 2-(5-aryl-5-oxopentyl)malonates was electrooxidized in methanol, in the presence of catalytic amount of potassium iodide, to give the corresponding dimethyl 2-aroylcyclopentane-1,1-dicarboxylates in high yields.The reactions were carried out under extremely mild reaction conditions, in which the optimal amount of electrolytic current ranged from 2.24 to 2.35 Fmol(-1). The reaction presumably proceeded via a two-electron oxidation process, in which iodide ions played an important role as the electron carrier between the anode and the substrate. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.12.104

文献信息

• Anodic cyclization of dimethyl 2-(5-aryl-5-oxopentyl)malonates into the corresponding dimethyl 2-aroylcyclopentane-1,1-dicarboxylates
  作者：Mitsuhiro Okimoto、Haruki Yamamori、Masayuki Hoshi、Takashi Yoshida

  DOI：10.1016/j.tetlet.2013.12.104

  日期：2014.2

  A wide range of dimethyl 2-(5-aryl-5-oxopentyl)malonates was electrooxidized in methanol, in the presence of catalytic amount of potassium iodide, to give the corresponding dimethyl 2-aroylcyclopentane-1,1-dicarboxylates in high yields.The reactions were carried out under extremely mild reaction conditions, in which the optimal amount of electrolytic current ranged from 2.24 to 2.35 Fmol(-1). The reaction presumably proceeded via a two-electron oxidation process, in which iodide ions played an important role as the electron carrier between the anode and the substrate. (C) 2014 Elsevier Ltd. All rights reserved.