Pracinostat hydrochloride

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Pracinostat hydrochloride
• 英文别名: (E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide;dihydrochloride
• 化学式: C20H32Cl2N4O2
• 分子量: 431.4
• InChiKey: CHLPUMOYKYJFFH-PFNYCKIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.08
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70.4
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Polymorphic forms of 3-[(2-butyl-1-(2-diethylamino-ethyl)-1H-benzoimidazol-5-yl]-N-hydroxy-acrylamide and uses thereof
  申请人：MEI PHARMA, INC.

  公开号：US10626092B2

  公开（公告）日：2020-04-21

  Crystalline polymorph forms of 3-[2-butyl-1-(2-diethylamino-ethyl)-1H-benzoimidazol-5-yl]-N-hydroxy-acrylamide are described. Pharmaceutical compositions and the uses of such compounds, compound forms, and compositions for the treatment of diseases and conditions are also presented.

  描述了 3-[2-丁基-1-(2-二乙氨基-乙基)-1H-苯并咪唑-5-基]-N-羟基-丙烯酰胺的结晶多晶型。此外，还介绍了用于治疗疾病和病症的药物组合物以及此类化合物、化合物形式和组合物的用途。
• POLYMORPHIC FORMS OF 3-[2-BUTYL-1-(2-DIETHYLAMINO-EHTYL)-1H-BENZOIMIDAZOL-5-YL]-N-HYDROXY-ACRYLAMIDE AND USES THEREOF
  申请人：MEI Pharma, Inc.

  公开号：EP3452035A1

  公开（公告）日：2019-03-13
• POLYMORPHIC FORMS OF 3-[2-BUTYL-1-(2-DIETHYLAMINO-ETHYL)-1H-BENZOIMIDAZOL-5-YL]-N-HYDROXY-ACRYLAMIDE AND USES THEREOF
  申请人：MEI Pharma, Inc.

  公开号：EP3452035B1

  公开（公告）日：2021-07-07
• [EN] POLYMORPHIC FORMS OF 3-[2-BUTYL-1-(2-DIETHYLAMINO-EHTYL)-1H-BENZOIMIDAZOL-5-YL]-N-HYDROXY-ACRYLAMIDE AND USES THEREOF<br/>[FR] FORMES POLYMORPHES DE 3-[2-BUTYL-1-(2-DIÉTHYLAMINO-ETHYL)-1H-BENZOIMIDAZOL-5-YL]-N-HYDROXY-ACRYLAMIDE ET LEURS UTILISATIONS
  申请人：MEI PHARMA INC

  公开号：WO2017192451A1

  公开（公告）日：2017-11-09

  Crystalline polymorph forms of 3-[2-butyl-1-(2-diethylamino-ethyl)-1H-benzoimidazol-5-yl]-N-hydroxy-acrylamide are described. Pharmaceutical compositions and the uses of such compounds, compound forms, and compositions for the treatment of diseases and conditions are also presented.