9H-indeno<2,1-c>-3(2H)-pyridazinone | 100595-19-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 9H-indeno<2,1-c>-3(2H)-pyridazinone
• 英文别名: 9H-indeno[2,1-c]pyridazin-3(2H)-one；3H-Indeno(2,1-c)pyridazin-3-one, 2,9-dihydro-；2,9-dihydroindeno[2,1-c]pyridazin-3-one
• CAS: 100595-19-5
• 化学式: C₁₁H₈N₂O
• 分子量: 184.197
• InChiKey: RBKCMQDUWRRYJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  9H-indeno<2,1-c>-3(2H)-pyridazinone 在 硫酸 、 双氧水 、 potassium nitrate 、 三氯氧磷 作用下， 以 甲酸 为溶剂， 反应 1.0h， 生成 3-chloro-6-nitro-9H-indeno[2,1-c]pyridazine 1-oxide
  参考文献：
  名称：

  Synthesis and “in Vitro” Antimicrobial Properties ofN-Oxide Derivatives Based on Tricyclic Indeno[2,1-c]pyridazine and Benzo[f]cinnoline Systems

  摘要：

  A number of 9H-indeno[2,1-c]pyridazine N-oxides (3a-c) and benzo[f]cinnoline N-oxides (4,5a-c) have been synthesized and tested for antimicrobial activity. All new products were inactive against Gram negative bacteria and fungi. In contrast, among the compounds synthesized, 3b, 4b and 5b showed a moderate activity against Gram positive Staphylococcus aureus and Staphylococcus epidermidis. Of the present series, the 9-nitro-benzo[f]cinnoline N-oxide 5b possessed the highest activity especially against Trichomonas vaginalis (MIC = 3.9 micrograms/ml).

  DOI：

  10.1002/1521-4184(200010)333:10<341::aid-ardp341>3.0.co;2-u
• 作为产物：
  描述：

  2-indanone-1-acetic acid ethyl ester 在 溴 、 一水合肼 、 溶剂黄146 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 反应 6.0h， 生成 9H-indeno<2,1-c>-3(2H)-pyridazinone
  参考文献：
  名称：

  Pinna; Curzu; Loriga, Farmaco, Edizione Scientifica, 1985, vol. 40, # 12, p. 979 - 986

  摘要：

  DOI：

文献信息

• Barlocco, Daniela; Bergomi, Marzia; Menta, Ernesto, Recueil des Travaux Chimiques des Pays-Bas, 1996, vol. 115, # 1, p. 25 - 30
  作者：Barlocco, Daniela、Bergomi, Marzia、Menta, Ernesto、Palumbo, Manlio、Cignarella, Giorgio

  DOI：——

  日期：——
• PINNA, G. A.;CURZU, M. M.;LORIGA, M.;CIGNAREL, G.;BARLOCCO, D.;MALANDRINO+, FARMACO. ED. SCI., 1985, 40, N 12, 979-986
  作者：PINNA, G. A.、CURZU, M. M.、LORIGA, M.、CIGNAREL, G.、BARLOCCO, D.、MALANDRINO+

  DOI：——

  日期：——
• Synthesis and “in Vitro” Antimicrobial Properties ofN-Oxide Derivatives Based on Tricyclic Indeno[2,1-c]pyridazine and Benzo[f]cinnoline Systems
  作者：Elisabetta Gavini、Claudia Juliano、Antonio Mulè、Gerolamo Pirisino、Gabriele Murineddu、Gérard A. Pinna

  DOI：10.1002/1521-4184(200010)333:10<341::aid-ardp341>3.0.co;2-u

  日期：2000.10

  A number of 9H-indeno[2,1-c]pyridazine N-oxides (3a-c) and benzo[f]cinnoline N-oxides (4,5a-c) have been synthesized and tested for antimicrobial activity. All new products were inactive against Gram negative bacteria and fungi. In contrast, among the compounds synthesized, 3b, 4b and 5b showed a moderate activity against Gram positive Staphylococcus aureus and Staphylococcus epidermidis. Of the present series, the 9-nitro-benzo[f]cinnoline N-oxide 5b possessed the highest activity especially against Trichomonas vaginalis (MIC = 3.9 micrograms/ml).
• Pinna; Curzu; Loriga, Farmaco, Edizione Scientifica, 1985, vol. 40, # 12, p. 979 - 986
  作者：Pinna、Curzu、Loriga、Cignarella、Barlocco、Malandrino

  DOI：——

  日期：——