2,2-Dibromo-2-methanesulfonyl-1-phenyl-ethanone | 90476-23-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-Dibromo-2-methanesulfonyl-1-phenyl-ethanone
• 英文别名: 2,2-dibromo-2-methylsulfonyl-1-phenylethanone
• CAS: 90476-23-6
• 化学式: C₉H₈Br₂O₃S
• 分子量: 356.035
• InChiKey: RZIPAFVZQXOKBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2-Dibromo-2-methanesulfonyl-1-phenyl-ethanone 在 sodium hydroxide 作用下， 反应 0.5h， 以98%的产率得到dibromomethyl-methyl sulfone
  参考文献：
  名称：

  Chemoselective mono halogenation of β-keto-sulfones using potassium halide and hydrogen peroxide; synthesis of halomethyl sulfones and dihalomethyl sulfones

  摘要：

  The synthesis of alpha-halo beta-keto-sulfones using potassium halide and hydrogen peroxide as a chemoselective mono halogenation reagent and the synthesis of alpha, alpha-symmetrical and asymmetrical dihalo beta-keto-sulfones and alpha-halo, alpha-alkyl and beta-keto-sulfones is described. Base induced cleavage of alpha-halo beta-keto-sulfones, alpha,alpha-dihalo beta-keto-sulfones, and alpha-halo, alpha-alkyl beta-keto-sulfones afforded the corresponding halomethyl sulfones, dihalomethyl sulfones and haloalkyl sulfones. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.129
• 作为产物：
  描述：

  2-bromo-2-methylsulfonyl-1-phenylethanone 在 溴 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以98%的产率得到2,2-Dibromo-2-methanesulfonyl-1-phenyl-ethanone
  参考文献：
  名称：

  Chemoselective mono halogenation of β-keto-sulfones using potassium halide and hydrogen peroxide; synthesis of halomethyl sulfones and dihalomethyl sulfones

  摘要：

  The synthesis of alpha-halo beta-keto-sulfones using potassium halide and hydrogen peroxide as a chemoselective mono halogenation reagent and the synthesis of alpha, alpha-symmetrical and asymmetrical dihalo beta-keto-sulfones and alpha-halo, alpha-alkyl and beta-keto-sulfones is described. Base induced cleavage of alpha-halo beta-keto-sulfones, alpha,alpha-dihalo beta-keto-sulfones, and alpha-halo, alpha-alkyl beta-keto-sulfones afforded the corresponding halomethyl sulfones, dihalomethyl sulfones and haloalkyl sulfones. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.129

文献信息

• Process for preparing haloacetophenone derivative
  申请人：SUMITOMO SEIKA CHEMICALS CO., LTD.

  公开号：EP0798294A2

  公开（公告）日：1997-10-01

  An α-halo(methylthio)acetophenone of formula (2): wherein X is chlorine or bromine can be produced by treating the corresponding methylthioacetophenone with a halogenating agent in the presence of an alcohol. Oxidation of the α-halo(methylthio)acetophenone yields the corresponding α-halo(methylsulphonyl)acetophenone.

  式（2）的α-卤代（甲硫基）苯乙酮： 其中 X 为氯或溴，可通过在醇存在下用卤化剂处理相应的甲硫基苯乙酮制得。氧化 α-卤代(甲硫基)苯乙酮可得到相应的 α-卤代(甲磺酰基)苯乙酮。
• Grosset, Stuart J.; Dubey, Pramod K.; Gill, Glen H., Canadian Journal of Chemistry, 1984, vol. 62, p. 798 - 807
  作者：Grosset, Stuart J.、Dubey, Pramod K.、Gill, Glen H.、Cameron, Stanley T.、Gardner, Patrick A.

  DOI：——

  日期：——
• GROSSERT, J. S.;DUBEY, P. K.;GILL, G. H.;CAMERON, T. S.;GARDNER, P. A., CAN. J. CHEM., 1984, 62, N 4, 798-807
  作者：GROSSERT, J. S.、DUBEY, P. K.、GILL, G. H.、CAMERON, T. S.、GARDNER, P. A.

  DOI：——

  日期：——
• Process for preparing alpha-haloacetophenone derivative
  申请人：SUMITOMO SEIKA CHEMICALS CO., LTD.

  公开号：EP0798294B1

  公开（公告）日：2000-06-14
• US5821388A
  申请人：——

  公开号：US5821388A

  公开（公告）日：1998-10-13