ethyl 4-methyl-6-(1-oxo-1-p-tolylpropan-2-yl)-5-phenylpicolinate | 1095874-47-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 4-methyl-6-(1-oxo-1-p-tolylpropan-2-yl)-5-phenylpicolinate
• 英文别名: Ethyl 4-methyl-6-[1-(4-methylphenyl)-1-oxopropan-2-yl]-5-phenylpyridine-2-carboxylate
• CAS: 1095874-47-7
• 化学式: C₂₅H₂₅NO₃
• 分子量: 387.478
• InChiKey: XDKOBUBXEASWKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  56.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl (2Z,4E)-2-azido-4-methyl-5-phenylpenta-2,4-dienoate 、 acetyl(p-toluoyl)diazomethane 在 三苯基膦 作用下， 以 甲苯 为溶剂， 反应 2.5h， 以81%的产率得到ethyl 4-methyl-6-(1-oxo-1-p-tolylpropan-2-yl)-5-phenylpicolinate
  参考文献：
  名称：

  A Cascade Approach to Pyridines from 2-Azido-2,4-dienoates and α-Diazocarbonyl Compounds

  摘要：

  A one-pot synthesis of substituted pyridines via a cascade reaction of 2-azido-24-dienoates with alpha-diazocarbonyl compounds and triphenylphosphine is reported. The process involves a Staudinger-Meyer reaction, a Wolff rearrangement, ail aza-Wittig reaction, and an electrocyclic ring- closure. The procedure is general and efficient. The substrates are readily available.

  DOI：

  10.1021/jo802159g

文献信息

• A Cascade Approach to Pyridines from 2-Azido-2,4-dienoates and α-Diazocarbonyl Compounds
  作者：Zheng-Bo Chen、Deng Hong、Yan-Guang Wang

  DOI：10.1021/jo802159g

  日期：2009.1.16

  A one-pot synthesis of substituted pyridines via a cascade reaction of 2-azido-24-dienoates with alpha-diazocarbonyl compounds and triphenylphosphine is reported. The process involves a Staudinger-Meyer reaction, a Wolff rearrangement, ail aza-Wittig reaction, and an electrocyclic ring- closure. The procedure is general and efficient. The substrates are readily available.