2-Phenyl-3-methyl-imidazo<1,2-a>pyrimidin | 28103-22-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Phenyl-3-methyl-imidazo<1,2-a>pyrimidin
• 英文别名: 3-Methyl-2-phenylimidazo[1,2-a]pyrimidine
• CAS: 28103-22-2
• 化学式: C₁₃H₁₁N₃
• 分子量: 209.25
• InChiKey: BAFRXGZWAHEAHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Phenyl-3-methyl-imidazo<1,2-a>pyrimidin 以85%的产率得到
  参考文献：
  名称：

  DOUGHTY D. G.; GLOVER E. E.; VAUGHAN K. D., J. CHEM. SOC. PERKIN TRANS., PART 1 , 1977, NO 1, 78-80

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3,5-三嗪-2,4,6-三胺,N,N'''-1,2-乙二基二[N-[3-[[4,6-二[丁基(2,2,6,6-四甲基-4-哌啶基)氨基]-1,3,5-三嗪-2-基]氨基]丙基]-N,N''-二丁基-N,N''-二(2,2,6,6-四甲基-4-哌啶基)- 、 (1-oxo-1-phenylpropan-2-yl) 2,4-dinitrobenzenesulfonate 在 sodium carbonate 作用下， 以 poly(ethylene glycol-400) 为溶剂， 反应 0.5h， 生成 2-Phenyl-3-methyl-imidazo<1,2-a>pyrimidin
  参考文献：
  名称：

  高价碘（III）磺酸盐在液体PEG-400中介导的2-Arylimidazo [1,2-a]嘧啶的合成

  摘要：

  PEG-400 [聚（乙二醇-400）]在与酮[羟基（2,4,4）反应的单罐合成2-芳基咪唑[1,2- a ]嘧啶中用作“绿色”可回收溶剂-二硝基苯磺酰氧基）-碘]苯（HDNIB）和2-氨基嘧啶。已经观察到速率显着提高和产量提高。

  DOI：

  10.1002/jccs.200900094

文献信息

• CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING THE SAME
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US20160285011A1

  公开（公告）日：2016-09-29

  An organic light-emitting device including a first electrode as an anode; a second electrode as a cathode and facing the first electrode; and an organic layer between the first electrode and the second electrode, the organic layer including an emission layer, a hole transport region between the first electrode and the emission layer, and an electron transport region between the emission layer and the second electrode, where at least one selected from the emission layer and the electron transport region includes at least one selected from condensed cyclic compounds represented by Formula 1: A 2 -(A 1 ) n1 .  Formula 1

  一种有机发光器件，包括第一电极作为阳极；第二电极作为阴极，且与第一电极相对；以及位于第一电极和第二电极之间的有机层，该有机层包括一个发射层，在第一电极和发射层之间的一个空穴传输区域，以及在发射层和第二电极之间的一个电子传输区域，其中发射层和电子传输区域中的至少一个包括由Formula 1：A2-(A1)n1表示的至少一个紧缩环化合物中的至少一个。
• CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：US20180097186A1

  公开（公告）日：2018-04-05

  A condensed cyclic compound and an organic light-emitting device including the same are provided. The organic light-emitting device includes a first electrode, a second electrode, and an organic layer disposed between the first electrode and the second electrode. The organic layer includes the condensed cyclic compound represented by Formula 1: in Formula 1, A 11 is a C 1 -C 60 heterocyclic group, A 12 is a C 5 -C 60 carbocyclic group or a C 1 -C 60 heterocyclic group, X 11 is O or S, X 12 is C, X 13 is selected from N, C, and C(R 13 ), X 14 is selected from N, C, and C(R 14 ), and X 13 and X 14 are linked via a single bond or a double bond.

  提供一种浓缩的环状化合物和包括该化合物的有机发光器件。有机发光器件包括第一电极、第二电极和位于第一电极和第二电极之间的有机层。有机层包括由式1表示的浓缩的环状化合物：在式1中，A11是C1-C60杂环基团，A12是C5-C60碳环基团或C1-C60杂环基团，X11是O或S，X12是C，X13选自N、C和C(R13)，X14选自N、C和C(R14)，X13和X14通过单键或双键连接。
• ORGANIC LIGHT-EMITTING DEVICE
  申请人：Samsung Display Co., Ltd.

  公开号：US20170179404A1

  公开（公告）日：2017-06-22

  An organic light-emitting device includes: a first electrode; a second electrode facing the first electrode; and an organic layer between the first electrode and the second electrode, the organic layer including an emission layer, wherein the organic layer includes a first compound represented by Formula 1 and a second compound represented by Formula 501. The organic light-emitting device including the first compound and the second compound may have low driving voltage, high efficiency, and high luminance.

  有机发光器件包括：第一电极；面向第一电极的第二电极；以及在第一电极和第二电极之间的有机层，该有机层包括一个发射层，其中有机层包括由公式1表示的第一化合物和由公式501表示的第二化合物。包括第一化合物和第二化合物的有机发光器件可能具有低驱动电压、高效率和高亮度。
• INDOLE COMPOUNDS AS EZH2 INHIBITORS AND USES THEREOF
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：EP3885343A1

  公开（公告）日：2021-09-29

  The present disclosure provides compounds of Formula (II). The compounds described herein are inhibitors of histone methyltransferases (e.g., enhancer of zeste homolog 1 (EZH1) and enhancer of zeste homolog 2 (EZH2)) and are useful in treating and/or preventing a broad range of diseases (e.g., proliferative diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein. Further provided in the present disclosure are methods of identifying EZH1 and/or EZH2 inhibitors.

  本公开提供了式（II）化合物。 本文所述化合物是组蛋白甲基转移酶（如泽斯特同源增强子 1 (EZH1) 和泽斯特同源增强子 2 (EZH2)）的抑制剂，可用于治疗和/或预防多种疾病（如增殖性疾病）。本公开还提供了包括或使用本文所述化合物的药物组合物、试剂盒、方法和用途。本公开还提供了鉴定EZH1和/或EZH2抑制剂的方法。
• Organic light-emitting device
  申请人：Samsung Display Co., Ltd.

  公开号：US10032994B2

  公开（公告）日：2018-07-24

  An organic light-emitting device including a first electrode, a second electrode facing the first electrode, and an organic layer between the first electrode and the second electrode and including an emission layer, wherein the organic layer includes a first compound and a second compound; the first compound is represented by one selected from Formulae 1-1 to 1-4, and does not include a nitrogen-containing heterocyclic group that includes *═N—*′ as a ring-forming moiety, and the second compound is represented by Formula 2:

  一种有机发光器件，包括第一电极、面对第一电极的第二电极以及位于第一电极和第二电极之间并包括发射层的有机层，其中有机层包括第一化合物和第二化合物；第一化合物由式1-1至1-4中选出的一种表示，且不包括以*═N-*′为成环分子的含氮杂环基团，第二化合物由式2表示：