2,2-bis-hydroxymethyl-butane-1,3-diol | 13167-50-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-bis-hydroxymethyl-butane-1,3-diol
• 英文别名: 2,2-Bis-hydroxymethyl-butan-1,3-diol；2,2-Bis(hydroxymethyl)-1,3-butanediol；2,2-bis(hydroxymethyl)butane-1,3-diol
• CAS: 13167-50-5
• 化学式: C₆H₁₄O₄
• 分子量: 150.175
• InChiKey: PUWSPTQNHGUGDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2-bis-hydroxymethyl-butane-1,3-diol 、 乙酸酐 生成 1,3-diacetoxy-2,2-bis-acetoxymethyl-butane
  参考文献：
  名称：

  DE962882

  摘要：

  公开号：
• 作为产物：
  描述：

  4-hydroxy-3,3-bis-(hydroxymethyl)-2-butanoate 在 镍 、 异丙醇 作用下， 生成 2,2-bis-hydroxymethyl-butane-1,3-diol
  参考文献：
  名称：

  US2752399

  摘要：

  公开号：

文献信息

• Efficient synthesis and properties of soluble aliphatic oligo(spiroorthocarbonate)s from pentaerythritol derivatives
  作者：Yasuyuki Mori、Atsushi Sudo、Takeshi Endo

  DOI：10.1002/pola.29327

  日期：——

  A series of soluble oligo(spiroorthocarbonate)s (OSOCs) were synthesized by polycondensation of tetraethylorthocarbonate with pentaerythritol derivatives. The pentaerythritol derivatives used herein were synthesized from pentaerythritol by attaching substituents on it to improve the solubility of themselves and the resulting OSOCs. The structures of the OSOCs were confirmed by NMR spectroscopy and

  通过原碳酸四乙酯与季戊四醇衍生物的缩聚反应，合成了一系列可溶性低聚原碳酸酯（OSOCs）。本文使用的季戊四醇衍生物由季戊四醇通过在其上连接取代基来合成，以改善其自身和所得的OSOC的溶解性。OSOC的结构已通过NMR光谱和MALDI-TOF质量分析确认。分级为4 +©2019 Wiley Periodicals，Inc.J.Polym。科学，A部分：Polym。化学 2019，57，792-798
• Compositions for tissue augmentation
  申请人：Kuros Biosurgery AG

  公开号：US20030232944A1

  公开（公告）日：2003-12-18

  Methods for making biomaterials for augmentation of soft and hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from at least a first and a second precursor component. The first precursor component contains at least two nucleophilic groups, and the second precursor component contains at least two electrophilic groups. The nucleophilic and electrophilic groups of the first and second precursor components form covalent linkages with each other at physiological temperatures. The precursors are selected based on the desired properties of the biomaterial. In the preferred embodiment, the first precursor is a siloxane. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to augment at least one vertebra of the spine (vertebroplasty).

  本文描述了用于增强软组织和硬组织的生物材料制备方法，包含形成生物材料的前体物质的套件以及所得到的生物材料。生物材料由至少第一和第二前体成分形成。第一前体成分含有至少两个亲核基团，第二前体成分含有至少两个电子亲和基团。第一和第二前体成分的亲核和电子亲和基团在生理温度下形成共价键。前体物质根据所需的生物材料性质进行选择。在首选实施例中，第一前体是硅氧烷。可选地，生物材料包含添加剂，例如流变剂、放射性不透明剂或生物活性剂。在首选实施例中，生物材料用于增强脊柱的至少一个椎体（椎体成形术）。
• COMPOSITIONS FOR TISSUE AUGMENTATION
  申请人：Molenberg Aaldert Rens

  公开号：US20100034769A1

  公开（公告）日：2010-02-11

  Methods for making biomaterials for augmentation of soft and hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from at least a first and a second precursor component. The first precursor component contains at least two nucleophilic groups, and the second precursor component contains at least two electrophilic groups. The nucleophilic and electrophilic groups of the first and second precursor components form covalent linkages with each other at physiological temperatures. The precursors are selected based on the desired properties of the biomaterial. In the preferred embodiment, the first precursor is a siloxane. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to augment at least one vertebra of the spine (vertebroplasty).

  本文描述了用于增强软组织和硬组织的生物材料制备方法，包含形成生物材料的前体物质的套件，以及所得到的生物材料。生物材料由至少一个第一前体组分和一个第二前体组分形成。第一前体组分含有至少两个亲核基团，第二前体组分含有至少两个电离基团。第一和第二前体组分的亲核和电离基团在生理温度下形成共价键。前体物质的选择基于所需生物材料的性质。在首选实施例中，第一前体是硅氧烷。可选地，生物材料含有添加剂，例如流变剂、放射性不透明剂或生物活性剂。在首选实施例中，生物材料用于增强脊柱的至少一个椎体（椎体成形术）。
• Plastic composition, production method, and use of same
  申请人：ATP Aicher + Tröbs Produktentwicklung GmbH

  公开号：US10662297B2

  公开（公告）日：2020-05-26

  The invention relates to a plastic composition, comprising (a) at least one polar thermoplastic polymer; (b) at least one metallic salt of an unsaturated aliphatic fatty acid; (c) at least one polyhydric alcohol, the melting point of which is no more than 80° C. below and no more than 50° C. above the melting point of the polymer (a); and (d) at least one further alcohol that is different from the alcohol (c), and the boiling point of which is no more than 100° C. below and no more than 80° C. above the melting point of the polymer (a).

  本发明涉及一种塑料组合物，包括：(a) 至少一种极性热塑性聚合物；(b) 至少一种不饱和脂肪族脂肪酸的金属盐；(c) 至少一种多元醇，其熔点不低于聚合物(a)熔点 80 摄氏度，不高于聚合物(a)熔点 50 摄氏度；以及(d) 至少一种不同于醇(c)的其他醇，其沸点不高于聚合物(a)熔点 80 摄氏度。(d) 至少一种不同于醇 (c) 的其他醇，其沸点不低于聚合物 (a) 熔点 100 摄氏度，不高于聚合物 (a) 熔点 80 摄氏度。
• Solid epoxidic cycloaliphatic hydroxylate resins, preparation process, and compositions of hardenable powerbase paints containing the said resins
  申请人：——

  公开号：US20040147691A1

  公开（公告）日：2004-07-29

  The invention concerns solid epoxidic cycloaliphatic hydroxylate resins, a process for the production thereof and compositions of hardenable powder-base paints containing the said resins. In particular, the said procedure enables solid epoxidic cycloaliphatic hydroxylate resins to be prepared with Tg≧35° C., epoxidic equivalent weight between 190 and 3,000, preferably between 250 and 2,000, Hydroxyl Number between 15 and 200 mg KOH/g, numeric molecular weight between 800 and 15,000, preferably lying between 1,000 and 10,000.

  本发明涉及固体环氧环脂族羟酸酯树脂、其生产工艺以及含有上述树脂的可硬化粉基涂料组合物。特别是，上述工艺可以制备固体环氧环脂族羟酸酯树脂，其 Tg≧35° C.，环氧当量重量在 190 至 3,000 之间，最好在 250 至 2,000 之间，羟基数在 15 至 200 mg KOH/g 之间，分子量在 800 至 15,000 之间，最好在 1,000 至 10,000 之间。