6-(环辛基氨基)喹啉-5,8-二酮 | 35961-95-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 6-(环辛基氨基)喹啉-5,8-二酮
• 英文名称: azaquinone
• 英文别名: Gangamicin；6-(cyclooctylamino)quinoline-5,8-dione
• CAS: 35961-95-6
• 化学式: C₁₇H₂₀N₂O₂
• 分子量: 284.358
• InChiKey: UCBSXTTUNYWOCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  59.1
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933499090

文献信息

• Novel quinones as disease therapies
  申请人：SLIL Biomedical Corporation

  公开号：US20020183512A1

  公开（公告）日：2002-12-05

  Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.

  提供了新型喹喔醌，以及包含这些新型喹喔醌的组合物。还提供了使用这些新型喹喔醌治疗包括癌症在内的各种适应症的方法。
• QUINONES AS DISEASE THERAPIES
  申请人：——

  公开号：US20030013677A1

  公开（公告）日：2003-01-16

  Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.

  本发明提供了新型的醌类化合物，以及包含这些新型醌类化合物的组合物。本发明还提供了使用这些新型醌类化合物治疗各种疾病，包括癌症的方法。
• Quinone prodrug compositions and methods of use
  申请人：Ashwell A. Mark

  公开号：US20060035963A1

  公开（公告）日：2006-02-16

  The present invention relates to quinone prodrug compositions and therapeutic methods using such prodrug compositions. Preferably, the quinone compounds of the invention are napthoquinone compounds such as β-lapachone or β-lapachone analogs. The quinone prodrug compositions of the invention exhibit improved solubility, stability, bioavailability, and pharmacokinetic properties, as well as improved plasma half-life in vivo.

  本发明涉及醌类前药组合物及使用这种前药组合物的治疗方法。本发明的醌类化合物最好是萘醌类化合物，例如β-萘醌或β-萘醌类似物。本发明的醌类前药组合物表现出改善的溶解度、稳定性、生物利用度和药物动力学特性，以及在体内改善的血浆半衰期。
• Furo- and pyrano-naphthoquinones and their use in the treatment of cancer
  申请人：SLIL Biomedical Corporation

  公开号：EP1574507A2

  公开（公告）日：2005-09-14

  Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.

  本研究提供了新型醌类化合物以及包含这些新型醌类化合物的组合物。还提供了使用新型醌类化合物治疗包括癌症在内的各种适应症的方法。
• Pharmaceutical compositions containing clofazimine for inhibiting Clostridium difficile activity
  申请人：KamTek, Inc.

  公开号：US10064860B2

  公开（公告）日：2018-09-04

  Methods for inhibiting the activity of Clostridium difficile in a subject comprises administering to the subject a pharmaceutical composition consisting of clofazimine and at least one pharmaceutically acceptable excipient. Pharmaceutical compositions consisting of clofazimine at least one pharmaceutically acceptable excipient are provided for treating Clostridium difficile infection and diseases or symptoms associated therewith.

  抑制受试者体内艰难梭菌活性的方法包括向受试者施用由氯氟嗪和至少一种药学上可接受的赋形剂组成的药物组合物。提供了由氯噻嗪和至少一种药学上可接受的赋形剂组成的药物组合物，用于治疗艰难梭菌感染和与之相关的疾病或症状。