4-Fluoro-8-methoxy-2-(trifluoromethyl)quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-Fluoro-8-methoxy-2-(trifluoromethyl)quinoline
• 化学式: C₁₁H₇F₄NO
• 分子量: 245.17
• InChiKey: AFFABMOFKWHRIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] QUINOLINE AS CONTRAST AGENT IN LASER INDUCED FLUORESCENCE (LIF) FOR LESIONS<br/>[FR] QUINOLÉINE EN TANT QU'AGENT DE CONTRASTE DANS UNE FLUORESCENCE INDUITE PAR LASER (LIF) DE LÉSIONS
  申请人：KONINKL PHILIPS ELECTRONICS NV

  公开号：WO2009022279A2

  公开（公告）日：2009-02-19

  The subject of this invention is to provide a compound and a contrast agent comprising a compound for a rapid, non-invasive examination process in the diagnosis of increased vascularity of lesions, especially cancerous lesions. The contrast agents comprising a compound and compounds used for diagnosis of lesions are compounds having a quinoline ring whereas the compounds may emit fluorescence in a range from 300 to 1200 nm. A method of diagnosing lesions is also subject of the present invention.
• [EN] COMPOSITIONS COMPRISING INDOLEAMINE 2,3- DIOXYGENASE-2 AND COENZYME Q INHIBITORS AND METHODS OF USE THEREOF<br/>[FR] COMPOSITIONS COMPRENANT DES INHIBITEURS DE L'INDOÉLAMINE 2,3-DIOXYGÉNASE-2 ET DU COENZYME Q ET PROCÉDÉS D'UTILISATION CORRESPONDANTS
  申请人：LANKENAU INST MEDICAL RES

  公开号：WO2009003164A1

  公开（公告）日：2008-12-31

  [EN] Compositions comprising coenzyme Q and ID02 inhibitors and methods of use thereof are provided.
  [FR] La présente invention concerne des compositions comprenant des inhibiteurs du coenzyme Q et de l'IDO2, ainsi que des procédés d'utilisation correspondants.