7-propoxy-1-indanone | 215362-16-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 7-propoxy-1-indanone
• 英文别名: 7-Propoxy-2,3-dihydroinden-1-one
• CAS: 215362-16-6
• 化学式: C₁₂H₁₄O₂
• 分子量: 190.242
• InChiKey: YKRSZHFIEVHTSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-propoxy-1-indanone 在 镍 氢气 、 对甲苯磺酸 作用下， 以 乙醇 、 甲苯 为溶剂， 25.0 ℃ 、500.0 kPa 条件下， 生成 (1R,1'R)-(-)-7-propoxy-1-(1-phenylethylamino)indan
  参考文献：
  名称：

  Structure Activity Relationship of Homochiral 7-Substituted 1-Aminoindans as 5-HT1A Receptor Ligands

  摘要：

  DOI：

  10.1002/(sici)1521-4184(199802)331:2<59::aid-ardp59>3.3.co;2-4
• 作为产物：
  描述：

  7-羟基-1-茚酮 、 溴丙烷 在 potassium carbonate 、 potassium iodide 作用下， 以 丙酮 为溶剂， 反应 30.0h， 以38%的产率得到7-propoxy-1-indanone
  参考文献：
  名称：

  Structure Activity Relationship of Homochiral 7-Substituted 1-Aminoindans as 5-HT1A Receptor Ligands

  摘要：

  DOI：

  10.1002/(sici)1521-4184(199802)331:2<59::aid-ardp59>3.3.co;2-4

文献信息

• Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same
  申请人：Hoveyda Hamid R.

  公开号：US20110105389A1

  公开（公告）日：2011-05-05

  The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (GRLN, growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and/or variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as antagonists or inverse agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, obesity and obesity-associated disorders, appetite or eating disorders, addictive disorders, cardiovascular disorders, gastrointestinal disorders, genetic disorders, hyperproliferative disorders, central nervous system disorders and inflammatory disorders.

  本发明提供了新型构象定义的大环化合物，已被证明是生长激素分泌素受体（GRLN，生长激素分泌素受体，GHS-R1a及其亚型、异构体和/或变种）的选择性调节剂。本文还描述了合成这些新型化合物的方法。这些化合物可用作生长激素分泌素受体的拮抗剂或逆向激动剂，以及用于治疗和预防一系列医学疾病，包括但不限于代谢和/或内分泌紊乱、肥胖和与肥胖相关的疾病、食欲或进食紊乱、成瘾紊乱、心血管疾病、胃肠道疾病、遗传疾病、过度增殖性疾病、中枢神经系统疾病和炎症性疾病。
• Design, synthesis, and structure&amp;ndash;activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury
  作者：Siyang Xiao、Wenxin Zhang、Hongjin Chen、Bo Fang、Yinda Qiu、Xianxin Chen、Lingfeng Chen、Shen Shu、Yali Zhang、Yunjie Zhao、Zhiguo Liu、Guang Liang

  DOI：10.2147/dddt.s160314

  日期：——

  Purpose: The purpose of this study was to design and synthesize novel 2-benzylidene-1-indanone derivatives for treatment of acute lung injury.Methods: A series of 39 novel 2-benzylidene-indanone structural derivatives were synthesized and evaluated for anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated murine primary macrophages.Results: Most of the obtained compounds effectively inhibited the LPS-induced expression of IL-6 and TNF-alpha. The most active compound, 8f, was found to significantly reduce LPS-induced pulmonary inflammation, as reflected by reductions in the concentration of total protein, inflammatory cell count, as well as the lung wet/dry ratio in bronchoalveolar lavage (BAL) fluid. Furthermore, 8f effectively inhibited mRNA expression of several inflammatory cytokines after LPS challenge in vitro and in vivo. Administration of 8f also blocked LPS-induced activation of the proinflammatory NF-kappa B/MAPK signaling pathway.Conclusion: The simple synthetic preparation and biological properties of these derivatives make these 2-benzylidene-indanone scaffolds promising new entities for the development of anti-inflammatory therapeutics for the treatment of acute lung injury.
• Structure Activity Relationship of Homochiral 7-Substituted 1-Aminoindans as 5-HT1A Receptor Ligands
  作者：Dorothea Landsiedel-Maier、August Wilhelm Frahm

  DOI：10.1002/(sici)1521-4184(199802)331:2<59::aid-ardp59>3.3.co;2-4

  日期：1998.2