1-[2-(4-chlorophenyl)ethyl]-N-(2-methylquinolin-6-yl)-5-oxopyrrolidine-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-[2-(4-chlorophenyl)ethyl]-N-(2-methylquinolin-6-yl)-5-oxopyrrolidine-3-carboxamide
• 化学式: C₂₃H₂₂ClN₃O₂
• 分子量: 407.9
• InChiKey: RKVXPRPCHGDCGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  62.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• TIP60 INHIBITORS
  申请人：Greene Mark I

  公开号：US20140187579A1

  公开（公告）日：2014-07-03

  This invention is in the fields of immunology and autoimmunity. More particularly it concerns pharmaceutical compositions comprising compounds which are useful agents for inhibiting the functions of TIP60 and the use of such compounds in the treatment of an individual suffering, for example, from ulcerative colitis and other irritable bowel diseases.
• US9701631B2
  申请人：——

  公开号：US9701631B2

  公开（公告）日：2017-07-11
• [EN] TIP60 INHIBITORS<br/>[FR] INHIBITEURS DE TIP60
  申请人：UNIV PENNSYLVANIA

  公开号：WO2012075380A1

  公开（公告）日：2012-06-07

  This invention is in the fields of immunology and autoimmunity. More particularly it concerns pharmaceutical compositions comprising compounds which are useful agents for inhibiting the functions of TIP60 and the use of such compounds in the treatment of an individual suffering, for example, from ulcerative colitis and other irritable bowel diseases.