5-(1,1,2,2,3,3-hexafluoropropyl)-6-(trifluoromethyl)-2,3-dihydro-1H-pyrazin-6-ol

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: 5-(1,1,2,2,3,3-hexafluoropropyl)-6-(trifluoromethyl)-2,3-dihydro-1H-pyrazin-6-ol
• 化学式: C₈H₇F₉N₂O
• 分子量: 318.142
• InChiKey: HRQCDFNQJXTGNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  44.6
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  6-Hydroundecafluoro-2,3-epoxyhexane 、 乙二胺 以 二乙二醇二甲醚 为溶剂， 反应 1.0h， 以64%的产率得到5-(1,1,2,2,3,3-hexafluoropropyl)-6-(trifluoromethyl)-2,3-dihydro-1H-pyrazin-6-ol
  参考文献：
  名称：

  Synthesis of polyfluoroalkylated 1,4-diazinols and 1,4-oxazinols using polyfluoro-2,3-epoxyalkanes32 + 13

  摘要：

  It has been found that the reactions of polyfluoro-2,3-epoxyalkanes with ethylenediamine and 2-aminoethanol yield 2,3-di(polyfluoroalkyl)- 1,5,6-trihydro-1,4-diazin-2-ols and 2,3-di(polyfluoroalkyl)-5,6-dihydro-1,4-oxazin-2-ols, respectively. In the case of unsymmetrical oxiranes mixtures of regioisomeric heterocyclic compounds have been obtained. These reactions were found to give some by products-N,N'-bis(polyfluoroacyl) ethylenediamines and N-polyfluoroacyl-2-aminoethanols. (C) 1998 Elsevier Science S.A.

  DOI：

  10.1016/s0022-1139(97)00102-4

文献信息

• Synthesis of polyfluoroalkylated 1,4-diazinols and 1,4-oxazinols using polyfluoro-2,3-epoxyalkanes32 + 13
  作者：L.V. Saloutina、A.Ya. Zapevalov、M.I. Kodess、V.I. Saloutin

  DOI：10.1016/s0022-1139(97)00102-4

  日期：1998.1

  It has been found that the reactions of polyfluoro-2,3-epoxyalkanes with ethylenediamine and 2-aminoethanol yield 2,3-di(polyfluoroalkyl)- 1,5,6-trihydro-1,4-diazin-2-ols and 2,3-di(polyfluoroalkyl)-5,6-dihydro-1,4-oxazin-2-ols, respectively. In the case of unsymmetrical oxiranes mixtures of regioisomeric heterocyclic compounds have been obtained. These reactions were found to give some by products-N,N'-bis(polyfluoroacyl) ethylenediamines and N-polyfluoroacyl-2-aminoethanols. (C) 1998 Elsevier Science S.A.