5-(3,4-Dimethoxy-phenyl)-2,3,5,6-tetrahydro-1H-benzo[a]phenanthridin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-(3,4-Dimethoxy-phenyl)-2,3,5,6-tetrahydro-1H-benzo[a]phenanthridin-4-one
• 英文别名: 5-(3,4-dimethoxyphenyl)-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one；5-(3,4-dimethoxyphenyl)-2,3,5,6-tetrahydro-1H-benzo[a]phenanthridin-4-one
• 化学式: C₂₅H₂₃NO₃
• 分子量: 385.463
• InChiKey: RQSWJOHFOJUOLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (3,4-dimethoxyphenyl)-methylene-2-naphthylamine 、 1,3-环己二酮 以 正丁醇 为溶剂， 反应 3.0h， 以54%的产率得到5-(3,4-Dimethoxy-phenyl)-2,3,5,6-tetrahydro-1H-benzo[a]phenanthridin-4-one
  参考文献：
  名称：

  Kozlov, N. G.; Gusak, K. N., Russian Journal of Organic Chemistry, 1999, vol. 35, # 3, p. 402 - 414

  摘要：

  DOI：

文献信息

• Inhibition of glutaminase C
  申请人：Cornell University

  公开号：US10987317B2

  公开（公告）日：2021-04-27

  The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.

  本发明涉及一种减少细胞或组织中谷氨酰胺酶 C 由谷氨酰胺产生谷氨酸的方法。该方法包括在有效减少谷氨酰胺产生谷氨酸的条件下抑制细胞或组织中谷氨酰胺酶 C 的活性。还公开了用于实施该方法的化合物。
• INHIBITION OF GLUTAMINASE C
  申请人：Cornell University

  公开号：US20200206149A1

  公开（公告）日：2020-07-02

  The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.
• [EN] MODULATORS OF RHO C ACTIVITY<br/>[FR] MODULATEURS DE L'ACTIVITE DE RHO C
  申请人：ICONIX PHARM INC

  公开号：WO2003043582A2

  公开（公告）日：2003-05-30

  Compounds of formula (1) modulate the activily of Rho C, wherein R1 is H, OH, or lower alkyl; R2, R3, R4, R5 and R6 are each independently H, halo, lower alkyl, OH, lower alkoxy, NH2, lower alkylamino, di(lower alkyl)amino, SH, lower alkylthio, NO2, or two residues together form a heterocyclic ring; R7, R8, R9 and R10 are each independently H, lower alkyl, OH, NH2, aryl, or aralkyl, where aryl and aralkyl are substituted with 0-3 moieties selected from the group consisting of halo, OH, NH2, lower alkyl, lower alkoxy, SH, lower alkylthio, and lower alkylamino; R11, R12, R13, R14, R15, and R16 are each independently H, halo, lower alkyl, OH, lower alkoxy, or NO2; or a pharmaceutically acceptable salt thereof.