2,2-dimethyl-5-(p-tolyl)-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one | 22949-41-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,2-dimethyl-5-(p-tolyl)-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one
• 英文别名: 2,2-dimethyl-5-(4-methylphenyl)-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one；2,2-dimethyl-5-(4-methylphenyl)-1,3,5,6-tetrahydrobenzo[a]phenanthridin-4-one
• CAS: 22949-41-3
• 化学式: C₂₆H₂₅NO
• 分子量: 367.491
• InChiKey: MPOFAOWBWVNNEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• MODULATORS OF TDP-43
  申请人：Alteron Therapeutics, Inc.

  公开号：EP3942038A1

  公开（公告）日：2022-01-26
• INHIBITIONS OF GLUTAMINASE C
  申请人：Cerione Richard A.

  公开号：US20120220610A1

  公开（公告）日：2012-08-30

  The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.
• [EN] MODULATORS OF TDP-43<br/>[FR] MODULATEURS DE TDP-43
  申请人：ALTERON THERAPEUTICS LLC

  公开号：WO2020190866A1

  公开（公告）日：2020-09-24

  Provided herein are compositions and methods for reducing toxicity associated with TAR DNA-binding protein 43. Certain embodiments of the present disclosure are related to compositions that treat, inhibit, reduce, prevent, or delay a disease or condition associated with TDP-43 toxicity, such as cystic fibrosis or neurodegenerative diseases. Certain embodiments of the present disclosure are related to methods of treating, inhibiting, reducing, preventing, or delaying a disease or condition associated with TDP-43 toxicity by administering compounds of any one of Formulas (I), (II), (III), (IV), (V), (VI), (VII), or (VIII) to a subject in need.