1-tert-Butoxycarbonylmethyl-cyclopentanecarboxylic acid benzyl ester | 181235-20-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-tert-Butoxycarbonylmethyl-cyclopentanecarboxylic acid benzyl ester
• 英文别名: Benzyl 1-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]cyclopentane-1-carboxylate
• CAS: 181235-20-1
• 化学式: C₁₉H₂₆O₄
• 分子量: 318.413
• InChiKey: MRJPFMAUCXPBTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-tert-Butoxycarbonylmethyl-cyclopentanecarboxylic acid benzyl ester 在 palladium on activated charcoal 乙胺嗪 、 氢气 、 1-羟基苯并三唑 作用下， 以 乙醇 、 二氯甲烷 、 三乙胺 为溶剂， 生成 {1-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-cyclopentyl}-acetic acid tert-butyl ester
  参考文献：
  名称：

  Inhibitors of MMP-1: an examination of P1′ Cα gem-disubstitution in the succinamide hydroxamate series

  摘要：

  The effect of P-1' C-alpha gem-disubstitution in a series of succinamide hydroxamate inhibitors of MMP-1 has been investigated. While in all cases P-1' gem-disubstitution led to loss of potency relative to the corresponding P-1' isobutyl and phenyl compounds 1 and 3, respectively, the loss of activity was less pronounced in certain instances, e.g., the P-1' gem-cyclohexyl analogue 12 (IC50 = 0.15 mu M). Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00303-4
• 作为产物：
  描述：

  溴乙酸叔丁酯 、 环戊烷羧酸苄酯 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 以66%的产率得到1-tert-Butoxycarbonylmethyl-cyclopentanecarboxylic acid benzyl ester
  参考文献：
  名称：

  Inhibitors of MMP-1: an examination of P1′ Cα gem-disubstitution in the succinamide hydroxamate series

  摘要：

  The effect of P-1' C-alpha gem-disubstitution in a series of succinamide hydroxamate inhibitors of MMP-1 has been investigated. While in all cases P-1' gem-disubstitution led to loss of potency relative to the corresponding P-1' isobutyl and phenyl compounds 1 and 3, respectively, the loss of activity was less pronounced in certain instances, e.g., the P-1' gem-cyclohexyl analogue 12 (IC50 = 0.15 mu M). Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00303-4

文献信息

• Inhibitors of MMP-1: an examination of P1′ Cα gem-disubstitution in the succinamide hydroxamate series
  作者：Ralph P. Robinson、John A. Ragan、Brian J. Cronin、Kathleen M. Donahue、Lori L. Lopresti-Morrow、Peter G. Mitchell、Lisa M. Reeves、Sue A. Yocum

  DOI：10.1016/0960-894x(96)00303-4

  日期：1996.7

  The effect of P-1' C-alpha gem-disubstitution in a series of succinamide hydroxamate inhibitors of MMP-1 has been investigated. While in all cases P-1' gem-disubstitution led to loss of potency relative to the corresponding P-1' isobutyl and phenyl compounds 1 and 3, respectively, the loss of activity was less pronounced in certain instances, e.g., the P-1' gem-cyclohexyl analogue 12 (IC50 = 0.15 mu M). Copyright (C) 1996 Elsevier Science Ltd