6-去氧基-D-葡萄糖胺 | 6018-53-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-去氧基-D-葡萄糖胺
• 英文名称: D-Quinovosamine
• 英文别名: 2-amino-2,6-dideoxy-D-glucose；D-gluco-2-Amino-3,4,5-trihydroxy-hexanal；2-Amino-2,6-didesoxy-D-glucose；D-Chinovosamin；2-Amino-2.6-didesoxy-D-glucose；Chinovosamin；(2R,3R,4R,5R)-2-amino-3,4,5-trihydroxyhexanal
• CAS: 6018-53-7
• 化学式: C₆H₁₃NO₄
• 分子量: 163.174
• InChiKey: NTBYIQWZAVDRHA-JGWLITMVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl 2-acetamido-3-O-acetyl-2,6-dideoxy-β-D-glucopyranoside 在 肼 作用下， 生成 6-去氧基-D-葡萄糖胺 、 D-岩藻糖基胺
  参考文献：
  名称：

  O型小肠结肠炎耶尔森氏菌血清型O：3脂多糖外核中6-脱氧-4-酮-己糖胺的鉴定及作用

  摘要：

  小肠结肠炎耶尔森氏菌血清型O：3脂多糖的外核（OC）区是六糖，对于外膜的完整性至关重要。它参与了对阳离子抗菌肽的抗性，并在感染的早期阶段发挥了毒性作用。我们在这里展示了OC六糖的近端的残基是很少遇到的4-酮己糖胺，2-乙酰氨基-2,6-二脱氧d -木糖-己-4- ulopyranose（SUG p）和华纳兄弟是UDP -GlcNAc-4,6-脱水酶负责这种罕见糖的核苷酸活化的形式的转换UDP-2-乙酰氨基-2-脱氧生物合成d -glucopyranose（UDP- d -Glc pNAC）到UDP-2-乙酰氨基-2,6-二脱氧d -木糖-己-4- ulopyranose（UDP- SUG p）。在水环境中，由于水合作用，这种糖的4-酮基以4-二羟基形式存在。此外，有证据表明，该二羟基功能的轴向4-羟基对于OC的生物学作用至关重要，即在噬菌体和肠结肠激肽受体结构以及单克隆抗体的表位中至关重要。

  DOI：

  10.1002/chem.200901255

文献信息

• DEVICE FOR AUTOMATED SYNTHESIS OF OLIGO- AND POLYSACCHARIDES
  申请人：Max-Planck-Gesellschat zu rFérderung der Wissenschaften e.V.

  公开号：US20220395800A1

  公开（公告）日：2022-12-15

  The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

  本发明通常涉及自动合成技术，更具体地，涉及一种用于在固体支持上自动合成寡糖和多糖的装置和方法。特别是，本发明涉及一种用于在固体支持上自动合成寡糖和多糖的装置，包括反应容器、试剂储存组件、试剂输送系统、冷却装置用于冷却反应容器和预冷装置用于预冷待供应试剂的组成部分。
• 6-Deoxyglucosamine-peptide derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0015468A1

  公开（公告）日：1980-09-17

  Novel 6-deoxyglucosamine-peptide derivatives of the formula wherein R is hydrogen or an organic acid residue or alkoxy-carbonyl; R1 is hydrogen or acyl; R2 is hydrogen or lower alkyl; R3 and R4 are each hydrogen or lower alkyl which may be substituted with hydroxyl; R5 and R6 are each carboxyl which may be esterified or amidated; R7 is hydrogen or aralkyl; and (D) and (L) each indicate configurations if their respective carbon atoms are asymmetric or a salt thereof have immunostimulatory activity.

  式中的新型 6-脱氧葡糖胺肽衍生物 式中 R 是氢或有机酸残基或烷氧基羰基； R1 是氢或酰基 R2 是氢或低级烷基 R3 和 R4 均为氢或可被羟基取代的低级烷基； R5 和 R6 各为羧基，可被酯化或酰胺化； R7 是氢或芳烷基；以及 (D)和(L)分别表示各自碳原子不对称时的构型 或其盐具有免疫刺激活性。
• NOVEL CELLULOSE-PRODUCING BACTERIA
  申请人：BIO-POLYMER RESEARCH CO., LTD.

  公开号：EP0834555A1

  公开（公告）日：1998-04-08

  This invention relates to a microorganism that is capable of producing a cellulosic product (referred to hereinafter as a "cellulose-producing bacterium") and belongs to a novel subspecies which is substantialy negative or very slightly positive in oxidation of acetates and lactates. This invention also relates to novel saccharide analog-resistant strains, amino acid analog-resistant strains and levan sucrase-defective strains. Further, this invention relates to a method for the production of cellulosic material (bacterial cellulose:"BC"), which comprises culturing these novel bactria and to bacterial cellulose which may be thus obtained. A larger amount of bacterial cellulose may be produced by culturing Acetobacter xylinum subsp. nonacetoxidans, the present resistant strains and the levan sucrase-defective strains, which have been derived and bred from the cellulose-producing bacteria, than by culturing the BPR 2001 strain in the medium containing especially sucrose or glucose as carbon sources.

  本发明涉及一种能够生产纤维素产品的微生物（以下简称为 "纤维素生产菌"），它属于一种新型亚种，在醋酸盐和乳酸盐的氧化过程中呈实质性阴性或极轻微阳性。本发明还涉及新型糖类似物抗性菌株、氨基酸类似物抗性菌株和莱万蔗糖缺陷菌株。 此外，本发明还涉及一种生产纤维素材料（细菌纤维素："BC"）的方法，其中包括培养这些新型菌株以及由此获得的细菌纤维素。 与在特别含有蔗糖或葡萄糖作为碳源的培养基中培养 BPR 2001 菌株相比，通过培养木醋杆菌亚种（Acetobacter xylinum subsp.
• Cartilage regeneration-promoting agent
  申请人：Eisai Food & Chemical Co., Ltd.

  公开号：EP1915991A1

  公开（公告）日：2008-04-30

  An object of the present invention is to provide an excellent cartilage regeneration-promoting agent that can promote regeneration of cartilage efficiently and is highly safe, and a medicine and a food that utilizes the cartilage regeneration-promoting agent. Thus, the present invention relates to a cartilage regeneration-promoting agent that includes at least one of hydroxytyrosol and a precursor of hydroxytyrosol, and to a medicine and a food that includes the cartilage regeneration-promoting agent.

  本发明的目的是提供一种可高效促进软骨再生且安全性高的优良软骨再生促进剂，以及一种使用该软骨再生促进剂的药品和食品。因此，本发明涉及一种包括羟基酪醇和羟基酪醇前体中至少一种的软骨再生促进剂，以及包括该软骨再生促进剂的药物和食品。
• Method for determining carbohydrates structure
  申请人：Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.

  公开号：US10359398B2

  公开（公告）日：2019-07-23

  The present invention relates to a method for determining in an expedient manner and with minimal sample consumption the structure of an unknown carbohydrate by using ion mobility-mass spectrometry (IM-MS) in negative ionization mode and fragmentation and a database containing structures of carbohydrates and/or of the fragments of the negative ions of carbohydrates, and for each of the structures of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the negative ion thereof, and for each of the structures of the fragments of the negative ions of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the fragment of the negative ion of the target carbohydrate.

  本发明涉及一种利用负离子化模式下的离子迁移质谱法（IM-MS）和碎裂法以及包含碳水化合物和/或碳水化合物负离子碎片结构的数据库，以便捷的方式和最少的样品消耗确定未知碳水化合物结构的方法、并为每种目标碳水化合物结构提供其负离子的碰撞截面值和质量电荷比值，为每种目标碳水化合物负离子碎片结构提供目标碳水化合物负离子碎片的碰撞截面值和质量电荷比值。