4-(3-nitrophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-6-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(3-nitrophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-6-carboxylic acid
• 化学式: C19H16N2O4
• mdl: MFCD00981504
• 分子量: 336.3
• InChiKey: SLZXXWORYGGPLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Methods and compounds to inhibit enveloped virus release
  申请人：Northwestern University

  公开号：US11369622B2

  公开（公告）日：2022-06-28

  A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.

  本发明公开了一种具有抗病毒活性的化合物，用于抑制包膜病毒从细胞中释放，包括抑制包膜病毒从细胞中释放的方法。该化合物的抗病毒活性包括抑制缔合复合物的形成或破坏缔合复合物的形成。关联复合物包括包膜病毒的 L-结构域基团和至少一种能够结合包膜病毒 L-结构域基团的细胞多肽或其片段。
• METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS
  申请人：Reed John C.

  公开号：US20090118135A1

  公开（公告）日：2009-05-07

  An assay for determining compounds that inhibit activity of a BCl-2 protein, or affect conversion of Bcl-2 from an antiapoptotic to a proapoptotic form are described. In addition, compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified.
• USE OF SMALL MOLECULE INHIBITORS TARGETING THE INTERACTION BETWEEN RAC GTPASE AND P67(PHOX)
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：US20160297835A1

  公开（公告）日：2016-10-13

  Inhibitors of p67 phox protein are provided herein, as well as pharmaceutical compositions and methods relating thereto.
• Methods and Compounds to Inhibit Enveloped Virus Release
  申请人：Northwestern University

  公开号：US20200368258A1

  公开（公告）日：2020-11-26

  A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.
• US9453022B2
  申请人：——

  公开号：US9453022B2

  公开（公告）日：2016-09-27