4-(2,4-dichlorophenyl)-2-methyl-5-oxo-7-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(2,4-dichlorophenyl)-2-methyl-5-oxo-7-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carbonitrile
• 化学式: C₂₃H₁₈Cl₂N₂O
• mdl: MFCD01445624
• 分子量: 409.315
• InChiKey: RGOLIVNEXHLRKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROIDAL RECEPTORS AND CALCIUM CHANNEL ACTIVITIES
  申请人：Michellys Pierre-Yves

  公开号：US20090298872A1

  公开（公告）日：2009-12-03

  The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorder associated with the activation of steroid hormone nuclear receptors.
• [EN] COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROIDAL RECEPTORS AND CALCIUM CHANNEL ACTIVITIES<br/>[FR] COMPOSES ET COMPOSITIONS UTILISES COMME MODULATEURS DE RECEPTEURS STEROIDIENS ET D'ACTIVITES DU CANAL CALCIUM
  申请人：IRM LLC

  公开号：WO2006066011A2

  公开（公告）日：2006-06-22

  [EN] The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activation of steroid hormone nuclear receptors.
  [FR] La présente invention concerne des composés, des compositions pharmaceutiques comprenant ces composés et des techniques d'utilisation de ces composés pour traiter ou prévenir des maladies ou des troubles associés à l'activation des récepteurs nucléaires d'hormone stéroïde.