N-[(8-hydroxyquinolin-7-yl)(4-methylphenyl)methyl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[(8-hydroxyquinolin-7-yl)(4-methylphenyl)methyl]acetamide
• 英文别名: N-[(8-hydroxyquinolin-7-yl)-(4-methylphenyl)methyl]acetamide
• 化学式: C₁₉H₁₈N₂O₂
• 分子量: 306.4
• InChiKey: PMYLAQSGBOUTCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCERS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES POUR L'UTILISATION DANS LE TRAITEMENT DE CANCERS
  申请人：PIRAMAL ENTPR LTD

  公开号：WO2014009891A1

  公开（公告）日：2014-01-16

  The present invention relates to the method for the treatment of cancer in a subject comprising administering to the subject in need thereof, a therapeutically effective amount of a rho GTPase inhibitor selected from a compound of formula (I) or a compound of formula (II), wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, in all their stereoisomeric or tautomeric forms, and mixtures thereof in all ratios and their pharmaceutically acceptable salts thereof. The present invention also relates to pharmaceutical compositions comprising a rho GTPase inhibitor selected from one or more compounds of formula (I) or compounds of formula (II) for use in the treatment of cancer.