2-[4-(2,2-Dimethyl-4-oxo-1,3,5,6-tetrahydrobenzo[a]phenanthridin-5-yl)-2-methoxyphenoxy]acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[4-(2,2-Dimethyl-4-oxo-1,3,5,6-tetrahydrobenzo[a]phenanthridin-5-yl)-2-methoxyphenoxy]acetic acid
• 化学式: C₂₈H₂₇NO₅
• 分子量: 457.5
• InChiKey: DWKIGRRXRTZSPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• MODULATORS OF TDP-43
  申请人：Alteron Therapeutics, Inc.

  公开号：EP3942038A1

  公开（公告）日：2022-01-26
• ACTIVATING PHOSPHORYLATION SITE ON GLUTAMINASE C
  申请人：Cerione Kristin Wilson

  公开号：US20130252983A1

  公开（公告）日：2013-09-26

  A method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting activating phosphorylation of glutaminase C under conditions effective to reduce production of glutamate from glutamine. Methods for treating or preventing a condition mediated by the activating phosphorylation of glutaminase C, detecting a condition mediated by the activating phosphorylation of glutaminase C, and screening for compounds capable of treating or preventing cancer are also disclosed.
• [EN] INHIBITION OF GLUTAMINASE C<br/>[FR] INHIBITION DE LA GLUTAMINASE C
  申请人：UNIV CORNELL

  公开号：WO2010111504A2

  公开（公告）日：2010-09-30

  The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.
• [EN] ACTIVATING PHOSPHORYLATION SITE ON GLUTAMINASE C<br/>[FR] ACTIVATION DU SITE DE PHOSPHORYLATION SUR LA GLUTAMINASE C
  申请人：UNIV CORNELL

  公开号：WO2012034123A1

  公开（公告）日：2012-03-15

  A method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting activating phosphorylation of glutaminase C under conditions effective to reduce production of glutamate from glutamine. Methods for treating or preventing a condition mediated by the activating phosphorylation of glutaminase C, detecting a condition mediated by the activating phosphorylation of glutaminase C, and screening for compounds capable of treating or preventing cancer are also disclosed.
• [EN] MODULATORS OF TDP-43<br/>[FR] MODULATEURS DE TDP-43
  申请人：ALTERON THERAPEUTICS LLC

  公开号：WO2020190866A1

  公开（公告）日：2020-09-24

  Provided herein are compositions and methods for reducing toxicity associated with TAR DNA-binding protein 43. Certain embodiments of the present disclosure are related to compositions that treat, inhibit, reduce, prevent, or delay a disease or condition associated with TDP-43 toxicity, such as cystic fibrosis or neurodegenerative diseases. Certain embodiments of the present disclosure are related to methods of treating, inhibiting, reducing, preventing, or delaying a disease or condition associated with TDP-43 toxicity by administering compounds of any one of Formulas (I), (II), (III), (IV), (V), (VI), (VII), or (VIII) to a subject in need.