N-benzyl-N-methyl-2-phenylquinoline-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-benzyl-N-methyl-2-phenylquinoline-4-carboxamide
• 化学式: C₂₄H₂₀N₂O
• mdl: MFCD02313973
• 分子量: 352.4
• InChiKey: BSYAMTMKRGNHEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• US20140275224A1
  申请人：——

  公开号：US20140275224A1

  公开（公告）日：2014-09-18
• US4684652A
  申请人：——

  公开号：US4684652A

  公开（公告）日：1987-08-04
• US4711890A
  申请人：——

  公开号：US4711890A

  公开（公告）日：1987-12-08
• [EN] CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION<br/>[FR] MODULATEURS DE LA CYTOSINE DÉSAMINASE POUR L'AMÉLIORATION DE LA TRANSFECTION D'ADN
  申请人：UNIV MINNESOTA

  公开号：WO2013074059A2

  公开（公告）日：2013-05-23

  Compounds and methods are provided for enhancing or boosting the transfection rate or efficiency of mammalian cells by foreign DNA, such as bacterial plasmid DNA. Compounds, including natural products and inventive synthetic compounds can increase the effectiveness of uptake and incorporation of foreign DNA by mammalian cells, such as human cells, by suppression of DNA cytosine deamination, which is believed to be a mechanism by which these cells eliminate foreign DNA. Inhibition of the cytosine deaminase enzymes by compounds as described herein serves to provide more effective transfection of eukaryotic cells by plasmids including engineered gene sequences. Transfection can be used to study cellular processes, or to cure genetic diseases in human patients. The inventive materials and methods increase the efficiency and effectiveness of such transfection techniques.
• [EN] 2-ARYL-4-QUINOLINECARBOXAMIDE DERIVATIVES FOR TREATING THYROID DISEASES<br/>[FR] DÉRIVÉS 2-ARYL-4-QUINOLÉINECARBOXAMIDE POUR LE TRAITEMENT DE MALADIES DE LA THYROÏDE
  申请人：ICAHN SCHOOL MED MOUNT SINAI

  公开号：WO2016004035A1

  公开（公告）日：2016-01-07

  The use of 2-arylquinolinecarboxamides of formula (I): is disclosed. The compounds are agonists at the TSH receptor (TSHR) and are therefore useful in the treatment of patients with thyroid dysfunction and in the management of differentiated thyroid cancer.