苄基-PEG4-乙酸叔丁酯 | 1443467-88-6

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苄基-PEG4-乙酸叔丁酯
• 英文名称: tert-butyl 1-phenyl-2,5,8,11-tetraoxatridecan-13-oate
• 英文别名: 1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid tert-butyl ester；Benzyl-PEG4-CH2CO2tBu；tert-butyl 2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]acetate
• CAS: 1443467-88-6
• 化学式: C₁₉H₃₀O₆
• 分子量: 354.444
• InChiKey: CPMNHAPGRNEYDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  25
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  苄基-PEG4-乙酸叔丁酯 在 4-二甲氨基吡啶 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 N-(6-(5-(1,2-dithiolan-3-yl)pentanamido)hexyl)-1-phenyl-2,5,8,11-tetraoxatridecan-13-amide
  参考文献：
  名称：

  Creating Protein-Imprinted Self-Assembled Monolayers with Multiple Binding Sites and Biocompatible Imprinted Cavities

  摘要：

  Imprinted monolayers have several advantages over bulk imprinted polymers such as excellent mass transfer of molecules into and out of imprinted sites and transduction of binding signals detected in real time. Protein-imprinted self-assembled monolayers (SAMs) were created with multiple binding sites and biocompatible imprinted cavities from functional thiols and novel disulfide compounds containing an oligoethylene glycol (OEG) terminal moiety and two amide groups incorporated in the chain (DHAP) in a biologically benign solution. DHAP played an important role in the formation of multiple binding sites and biocompatible cavities in addition to resisting nonspecific protein binding. The created protein-imprinted SAMs exhibited the excellent ability of specific binding of target proteins determined by multiple binding sites and imprinted cavities. The strategy generates tailor-made monolayer surfaces with specific protein binding and opens the possibility of controlled assembly of intellectual biomaterials and preparation of biosensors.

  DOI：

  10.1021/ja402423r
• 作为产物：
  描述：

  氯化苄 在 sodium hydride 、 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 35.75h， 生成 苄基-PEG4-乙酸叔丁酯
  参考文献：
  名称：

  Creating Protein-Imprinted Self-Assembled Monolayers with Multiple Binding Sites and Biocompatible Imprinted Cavities

  摘要：

  Imprinted monolayers have several advantages over bulk imprinted polymers such as excellent mass transfer of molecules into and out of imprinted sites and transduction of binding signals detected in real time. Protein-imprinted self-assembled monolayers (SAMs) were created with multiple binding sites and biocompatible imprinted cavities from functional thiols and novel disulfide compounds containing an oligoethylene glycol (OEG) terminal moiety and two amide groups incorporated in the chain (DHAP) in a biologically benign solution. DHAP played an important role in the formation of multiple binding sites and biocompatible cavities in addition to resisting nonspecific protein binding. The created protein-imprinted SAMs exhibited the excellent ability of specific binding of target proteins determined by multiple binding sites and imprinted cavities. The strategy generates tailor-made monolayer surfaces with specific protein binding and opens the possibility of controlled assembly of intellectual biomaterials and preparation of biosensors.

  DOI：

  10.1021/ja402423r

文献信息

• Design of Nanosystems for the Delivery of Quorum Sensing Inhibitors: A Preliminary Study
  作者：Supandeep Singh Hallan、Paolo Marchetti、Daria Bortolotti、Maddalena Sguizzato、Elisabetta Esposito、Paolo Mariani、Claudio Trapella、Roberta Rizzo、Rita Cortesi

  DOI：10.3390/molecules25235655

  日期：——

  Biofilm production is regulated by the Quorum Sensing system. Nowadays, Quorum Sensing represents an appealing target to design new compounds to increase antibiotics effects and avoid development of antibiotics multiresistance. In this research the use of liposomes to target two novel synthetic biofilm inhibitors is presented, focusing on a preformulation study to select a liposome composition for in vitro test. Five different liposome (LP) formulations, composed of phosphatidyl choline, cholesterol and charged surfactant (2:1:1, molar ratio) have been prepared by direct hydration and extrusion. As charged surfactants dicetyl phosphate didecyldimethylammonium chloride, di isobutyl phenoxy ethyl dimethyl benzyl ammonium chloride and stearylamine (SA) and have been used. Liposome charge, size and morphology were investigated by zeta potential, photon correlation spectroscopy, small angle x-ray spectroscopy and electron microscopy. LP-SA was selected for the loading of biofilm inhibitors and subjected to high performance liquid chromatography for entrapment capacity evaluation. LP-SA loaded inhibitors showed a higher diameter (223.6 nm) as compared to unloaded ones (205.7 nm) and a dose-dependent anti-biofilm effect mainly after 48 h of treatment, while free biofilm inhibitors loose activity. In conclusion, our data supported the use of liposomes as a strategy to enhance biofilm inhibitors effect.

  生物膜的生成受到群体感应系统的调控。如今，群体感应代表着一个吸引人的目标，用于设计新化合物以增强抗生素的效果并避免抗生素多重耐药性的发展。本研究介绍了利用脂质体来靶向两种新型合成生物膜抑制剂的方法，重点是进行预配方研究以选择适合体外测试的脂质体组成。通过直接水合和挤压法制备了五种不同的脂质体（LP）配方，由磷脂酰胆碱、胆固醇和带电表面活性剂（摩尔比2:1:1）组成。使用了带电表面活性剂二十二烷基磷酸二十二烷基二甲基氯化铵、二异丁基苯氧乙基二甲基苄基氯化铵和硬脂胺（SA）。通过ζ电位、光子相关光谱、小角度X射线光谱和电子显微镜研究了脂质体的电荷、大小和形态。选择了LP-SA用于载荷生物膜抑制剂，并进行了高效液相色谱法评估其包封能力。LP-SA载荷的抑制剂显示出较大的直径（223.6纳米），与未载荷的抑制剂（205.7纳米）相比，并且在治疗48小时后主要呈剂量依赖的抗生物膜效果，而游离的生物膜抑制剂失去活性。总之，我们的数据支持使用脂质体作为增强生物膜抑制剂效果的策略。
• [EN] BENZOTHIOPHENE DERIVATIVES AS ESTROGEN RECEPTOR INHIBITORS<br/>[FR] DÉRIVÉS BENZOTHIOPHÈNE COMME INHIBITEURS DU RÉCEPTEUR DES ŒSTROGÈNES
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2015000867A1

  公开（公告）日：2015-01-08

  A compound of formula (I), or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor.

  式(I)的化合物，或其药学上可接受的盐，含有所述化合物的组合物、组合物和药物，以及其制备方法。该发明还涉及所述化合物、组合物、组合物和药物的用途，例如作为雌激素受体活性的抑制剂，包括降解雌激素受体，治疗由雌激素受体介导的疾病和症状。
• ＢＥＴ蛋白質分解誘導作用を有するアミド化合物及びその医薬としての用途
  申请人：田辺三菱製薬株式会社

  公开号：WO2020009176A1

  公开（公告）日：2020-01-09

  がん細胞に対する細胞傷害作用、がん細胞におけるＢＥＴ蛋白質の分解を誘導する作用、およびＢＥＴ蛋白質とアセチル化ヒストンとの結合阻害作用に優れ、抗がん剤、ＢＥＴ蛋白質の分解誘導剤及びＢＥＴ蛋白質阻害剤として有用な化合物を提供すること。下記一般式（Ｉ）で表される化合物又はその薬理学的に許容される塩。｛式中、各記号は明細書中で定義した通りである。｝

  对癌细胞具有细胞损伤作用，诱导癌细胞中BET蛋白质的降解作用，以及优越的BET蛋白质与乙酰化组蛋白结合抑制作用，提供作为抗癌药物、BET蛋白质降解诱导剂和BET蛋白质抑制剂有用的化合物。该化合物或其药理学上可接受的盐由下述通用式（I）表示。式中，各符号如在说明书中定义。}
• 一种杂环化合物及其应用
  申请人：上海青玄生物科技有限公司

  公开号：CN113214227A

  公开（公告）日：2021-08-06

  本发明公开了一种杂环化合物及其应用。本发明提供了一种如式I所示的杂环化合物或其药学上可接受的盐。该杂环化合物能够降解ALK、c‑Met和ROS蛋白。
• [EN] PROTEOLYSIS TARGETING CHIMERAS (PROTACS) DIRECTED TO THE MODULATION OF THE ESTROGEN RECEPTOR<br/>[FR] CHIMÈRES CIBLANT LA PROTÉOLYSE (PROTACS) DIRIGÉES VERS LA MODULATION DU RÉCEPTEUR DES ŒSTROGÈNES
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2014108452A1

  公开（公告）日：2014-07-17

  A compound of formula (I): or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor.

  公式（I）的化合物：或其药用可接受盐，含有所述化合物的组合物、组合物和药物以及其制备方法。本发明还涉及所述化合物、组合物、组合物和药物的用途，例如作为雌激素受体活性的抑制剂，包括降解雌激素受体，治疗由雌激素受体介导的疾病和症状。