N-[(8-hydroxyquinolin-7-yl)(3-nitrophenyl)methyl]propanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[(8-hydroxyquinolin-7-yl)(3-nitrophenyl)methyl]propanamide
• 英文别名: N-[(8-hydroxyquinolin-7-yl)-(3-nitrophenyl)methyl]propanamide
• 化学式: C19H17N3O4
• 分子量: 351.4
• InChiKey: BCOXFXYXYHLXCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR SUCH
  申请人：Grimaldi Maurizio

  公开号：US20120245166A1

  公开（公告）日：2012-09-27

  Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for treating patients suffering from a neurodegenerative disease such as (without limitation) Alzheimer's, Parkinsons's, Lou Gehrig's (ALS) disease or memory or learning impairment. A neuronal human cell-based assay that assess NF-kB gene up-regulation using a luciferase reporter is also provided that screens for compounds useful in methods for enhancing memory or learning.
• US9095596B2
  申请人：——

  公开号：US9095596B2

  公开（公告）日：2015-08-04
• US9980969B2
  申请人：——

  公开号：US9980969B2

  公开（公告）日：2018-05-29
• [EN] TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR SUCH<br/>[FR] TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES, CAUSE D'AMÉLIORATION DE LA MÉMOIRE ET ANALYSE POUR ÉVALUER DES COMPOSÉS ASSOCIÉS
  申请人：SOUTHERN RES INST

  公开号：WO2011047129A1

  公开（公告）日：2011-04-21

  Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for treating patients suffering from a neurodegenerative disease such as (without limitation) Alzheimer's, Parkinsons's, and Lou Gehrig's (ALS) disease or memory or learning impairment. A neuronal human cell-based assay that assess NF-kB gene up-regulation using a luciferase reporter is also provided that screens for compounds useful in methods for enhancing memory or learning.