3-methylpyrocatechol diacetate | 35236-40-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 3-methylpyrocatechol diacetate
• 英文别名: 3-Methyl-brenzkatechin-diacetat；2,3-diacetoxy-toluene；2,3-Diacetoxy-toluol；3-Methylcatechol, diacetate；(2-acetyloxy-3-methylphenyl) acetate
• CAS: 35236-40-9
• 化学式: C₁₁H₁₂O₄
• 分子量: 208.214
• InChiKey: WSDQZFOBIKMDJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-methylpyrocatechol diacetate 在 乙酸铵 、 sodium hypochlorite 、 lithium aluminium tetrahydride 、 三氯化铝 、 potassium carbonate 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 二氯甲烷 、 溶剂黄146 、 氯苯 、 丙酮 为溶剂， 反应 11.67h， 生成 3-methyl-4,5-dimethoxy-β-nitrostyrene
  参考文献：
  名称：

  邻苯二酚O-甲基转移酶。12.用5，6-二羟基吲哚的氧化产物亲和标记活性位点。

  摘要：

  已经合成了5,6-二羟基吲哚（5,6-DHI）和5,6-DHI的一系列4-和/或7-甲基化类似物并评估了它们灭活纯化的大鼠肝儿茶酚O-甲基转移酶（COMT）的能力）。通过从混合物的培养中排除氧气，可以防止这些试剂使COMT失活，这表明必须将其氧化为相应的氨基色素。底物保护研究和动力学研究表明，酶活性的损失是由于COMT活性位点上的关键氨基酸残基通过与醌型氧化产物反应而被修饰而引起的。5,6-DHI的4-和/或7-甲基化类似物的COMT抑制活性与涉及在氨基染料的4或7位发生1,4迈克尔加成反应的机理相反。考虑到基本氨基染料结构上潜在的亲电子中心的数量，反应的位置可能会根据芳族取代模式而变化。优选的反应途径可以部分由亲核蛋白与亲电子配体上可能的进攻位点的并置决定，也可以部分由亲电子位点的反应性决定，该反应性可能随芳香环上的取代而改变。

  DOI：

  10.1021/jm00345a013
• 作为产物：
  描述：

  3-甲基苯邻二酚 生成 3-methylpyrocatechol diacetate
  参考文献：
  名称：

  Nuclear Substituted Analogs of Norepinephrine, Dihydroxyphenylalanine and Adrenochrome

  摘要：

  DOI：

  10.1021/ja01625a034

文献信息

• (Cycloalkyl) methyl silanes as external donors for polyolefin catalysts
  申请人：——

  公开号：US20020028893A1

  公开（公告）日：2002-03-07

  One aspect of the present invention relates to a catalyst system for use in olefinic polymerization, containing a solid titanium catalyst component; an organoaluminum compound having at least one aluminum-carbon bond; and an organosilicon compound comprising a (cycloalkyl)methyl group. Another aspect of the present invention relates to a method of making a catalyst for use in olefinic polymerization, involving the steps of reacting a Grignard reagent having a (cycloalkyl)methyl group with an orthosilicate to provide an organosilicon compound having a (cycloalkyl)methyl moiety; and combining the organosilicon compound with an organoaluminum compound having at least one aluminum-carbon bond and a solid titanium catalyst component to form the catalyst.

  本发明的一个方面涉及用于烯烃聚合的催化剂体系，包含固体钛催化剂组分；至少具有一个铝-碳键的有机铝化合物；以及包含一个（环烷基）甲基基团的有机硅化合物。本发明的另一个方面涉及一种制备用于烯烃聚合的催化剂的方法，包括以下步骤：将具有（环烷基）甲基基团的格氏试剂与正硅酸盐反应，以提供具有（环烷基）甲基基团的有机硅化合物；并将有机硅化合物与至少具有一个铝-碳键的有机铝化合物和固体钛催化剂组分结合，形成催化剂。
• Spherical catalyst for olefin polymerization
  申请人：Zhu Zhidong

  公开号：US20050164873A1

  公开（公告）日：2005-07-28

  Disclosed are catalyst systems and methods of making the catalyst systems/supports for the polymerization of an olefin containing a solid titanium catalyst component having a substantially spherical shape and containing a titanium compound and a support made from a magnesium compound and an alkyl silicate. The catalyst system may further contain an organoaluminum compound and an organosilicon compound. Also disclosed are methods of making an impact copolymer involving polymerizing an olefin to provide a polyolefin matrix and polymerizing a polyolefin rubber using a solid titanium catalyst component containing a titanium compound and a support made from a magnesium compound and an alkyl silicate.

  本发明涉及催化剂系统及其制备方法和聚合物的制备方法，其中所述催化剂系统/支撑体用于含有固体钛催化剂组分的烯烃聚合，该组分具有基本球形形状，包含钛化合物和由镁化合物和烷基硅酸酯制成的支撑体。所述催化剂系统还可以包含有机铝化合物和有机硅化合物。本发明还涉及一种制备共聚物的方法，该方法包括聚合烯烃以提供聚烯烃基体和使用含有钛化合物和由镁化合物和烷基硅酸酯制成的支撑体的固体钛催化剂组分聚合聚烯烃橡胶。
• Catalyst composition and process for polymerizing olefins
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0086645A2

  公开（公告）日：1983-08-24

  A process for producing an olefin polymer or copolymer which comprises polymerizing or copolymerizing olefins or copolymerizing an olefin with up to 5 mole% of a diolefin in the presence of a catalyst comprising a titanium catalyst component containing magnesium, titanium, halogen and an electron donor, an organoaluminum catalyst component and a third catalyst component, characterized in that said catalyst is composed of (A) a titanium catalyst component containing magnesium, titanium, halogen and an electron donor as essential ingredients, said electron donor being selected from the group consisting of (a) esters of polyfunctional compounds selected from polycarboxylic acids having 5 to 36 carbon atoms, polyhydroxy compounds having 6 to 28 carbon atoms and hydroxy-substituted carboxylic acids having 10 to 28 carbon atoms, (b) monocarboxylic acid esters of the formula RCOOR' in which each of R and R' represents a hydrocarbyl group having 1 to 20 carbon atoms, and at least one of them represents a branched-chain group, an alicyclic group, or an aryl ring-containing linear group, and (c) carbonic acid esters having 6 to 18 carbon atoms, (B) an organoaluminum compound, and (C) a substituted methylenediamine compound as a third component; and a catalyst composition used therefor.

  一种生产烯烃聚合物或共聚物的工艺，包括在催化剂存在下，使烯烃聚合或共聚，或使烯烃与不超过 5 摩尔%的二烯烃共聚，催化剂包括含镁、钛、卤素和电子供体的钛催化剂组分、有机铝催化剂组分和第三种催化剂组分，其特征在于所述催化剂由以下组分组成 (A) 以镁、钛、卤素和电子供体为基本成分的钛催化剂组分，所述电子供体选自以下 组别 (a) 选自具有 5 至 36 个碳原子的多羧酸、具有 6 至 28 个碳原子的多羟基化合物和 具有 10 至 28 个碳原子的羟基取代羧酸的多官能化合物的酯、 (b) 式 RCOOR'的单羧酸酯，其中每个 R 和 R'代表具有 1 至 20 个碳原子 的烃基，且至少有一个代表支链基、脂环基或含芳基环的线性基， 以及 (c) 具有 6 至 18 个碳原子的碳酸酯、 (B) 有机铝化合物，以及 (C) 作为第三组分的取代亚甲基二胺化合物； 以及用于其中的催化剂组合物。
• Catalyst for the polymerization of olefins
  申请人：Montedison S.p.A.

  公开号：EP0086472A2

  公开（公告）日：1983-08-24

  Catalysts for the polymerization of olefins, comprising the product of the reaction between: a) an Al-alkyl compound; b) an electron-donor compound capable of reacting with MgCl2 but which results not to be completely complexed with AI-triethyl at the equivalent point of a potentiometric titration under standard conditions and belonging to particular classes of compounds; c) a solid comprising a Ti compound having at least a Ti-halogen bond and an electron-donor compound belonging to particular classes of esters, both supported on a Mg halide in active form.

  用于烯烃聚合的催化剂，包括以下反应的产物： a) 铝烷基化合物 b) 一种电子供体化合物，能与氯化镁反应，但在标准条件下电位滴定的等效点不能与 AI-triethyl 完全络合，属于特定类别的化合物； c) 由至少有一个钛卤键的钛化合物和属于特定酯类的电子供体化合物组成的固 体，二者均以活性形式支撑在卤化镁上。
• Process for production of olefin polymer or copolymer
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0125911A1

  公开（公告）日：1984-11-21

  Polymerization or copolymerization of at least one olefin with or without up to about 5 mole % of a diolefin in the presence of a catalyust composed of (a) a solid titanium catalyst component containing magnesium, titanium, halogen and an electron donor, which is a reaction product of (iv) a titanium compound in the liquid state and a magnesium-containing solid carrier, said magnesium-containing solid carrier being formed by contacting (i) a magnesium compound in the liquid state not containing a titanium compound with (ii) a precipitant other than a titanium compound in the presence of or absence of (iii) an electron donor, said reaction product being formed by contacting the titanium compound (iv) in the liquid state and the magnesium-containing solid carrier, pre-treated or not pre-treated with the electron donor (iii), in the presence or absence of the electron donor (iii), the electron donor (iii) being used at least once throughout the period of formation of the magnesium-containing solid carrier and the formation of the reaction product, and (b) an organometallic compound of a metal selected from the group consisting of metals of Groups I to III of the periodic table; the improvement wherein said catalyst is composed of (A) a solid titanium catalyst component of (a) in which the electron donor (iii) is an ester selected from the group consisting of polycarboxylic acid esters and polyhydroxy compound esters. (B) the organometallic compound (b), and (C) an organosilicon compound having an Si-O-C or Si-N-C bond in its molecule.

  在由以下成分组成的催化剂存在下，至少一种烯烃与或不与最多约 5 摩尔%的二烯烃发生聚合或共聚合反应 (a) 含有镁、钛、卤素和电子供体的固体钛催化剂组分，它是 (iv) 液态钛化合物和含镁固体载体的反应产物，所述含镁固体载体是通过将 (i) 不含钛化合物的液态镁化合物与 (ii) 除钛化合物以外的沉淀剂在存在或不存在 (iii) 电子供体的情况下接触而形成的、在电子供体(iii)存在或不存在的情况下，将液态的钛化合物(iv)与预先用或未预先用电子供体(iii)处理过的含镁固体载体接触，形成所述反应产物，电子供体(iii)在形成含镁固体载体和形成反应产物的整个过程中至少使用一次，以及 (b) 选自元素周期表第Ⅰ至Ⅲ族金属组成的金属的有机金属化合物； 改进 其中所述催化剂由以下部分组成 (A) (a)的固体钛催化剂组分，其中电子供体(iii)是选自由聚羧酸酯和聚羟基化合物酯组成的组中的酯。 (B) 有机金属化合物 (b)，和 (C) 分子中具有 Si-O-C 或 Si-N-C 键的有机硅化合物。