cyclo-(Arg-Gly-Asp-DPhe-Acha) | 197172-76-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cyclo-(Arg-Gly-Asp-DPhe-Acha)
• 英文别名: Cyclotetrapeptide-24 aminocyclohexane carboxylate；2-[(9R,12S,18S)-9-benzyl-18-[3-(diaminomethylideneamino)propyl]-8,11,14,17,20-pentaoxo-7,10,13,16,19-pentazaspiro[5.14]icosan-12-yl]acetic acid
• CAS: 197172-76-2
• 化学式: C₂₈H₄₀N₈O₇
• 分子量: 600.675
• InChiKey: ROFCWWUBJHHVGZ-ZCNNSNEGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  247
• 氢给体数：
  8
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1-aminocyclohexanecarboxylic acid benzyl ester 在 哌啶 、 vanadyl trifluoromethanesulfonate 、 molybdenum(VI) oxychloride 、 palladium 10% on activated carbon 、 2,6-dinitrobenzoic anhydride 、 氢气 作用下， 以 甲醇 、 乙酸乙酯 、 1,2-二氯乙烷 为溶剂， 反应 32.0h， 生成 cyclo-(Arg-Gly-Asp-DPhe-Acha)
  参考文献：
  名称：

  Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same

  摘要：

  本发明揭示了一种环肽，其由以下式子(I)或(I')表示：其中R1在规范中有定义。此外，还揭示了包含该环肽的药物或化妆品组合物以及制备该组合物的方法。

  公开号：

  US20180298060A1

文献信息

• Method for preparing cyclopeptide
  申请人：National Tsing Hua University

  公开号：US10851134B2

  公开（公告）日：2020-12-01

  A method for preparing a cyclopeptide, which includes the following steps: (A) providing compounds represented by the following formulas (II-1) or (II′-1) and (II-2); (B) performing a reaction between the compounds of formulas (II-1) or (II′-1) and (II-2), to obtain a compound represented by the following formula (II-3) and (II′-3), respectively; (C) performing a reaction between the compound of formula (II-3) or (II′-3) and a compound represented by the following formula (II-4) or (II′-4), respectively, is performed, to obtain a compound represented by the following formula (II-5), and (II′-5), respectively; (D) performing a cyclization reaction of the compound of formula (II-5) or (II′-5) with a catalyst of formula (III), to obtain a compound represented by the following formula (I) or (I′), respectively. The formulas (I), (I′), (II-1) to (II-5), (II′-1) to (II′-5) and (III) are shown in the specification.

  一种制备环肽的方法，它包括下列步骤：(A)提供下式(Ⅱ-1)或(Ⅱ′-1)和(Ⅱ-2)所代表的化合物；(B)在式(Ⅱ-1)或(Ⅱ′-1)和(Ⅱ-2)的化合物之间进行反应，分别得到下式(Ⅱ-3)和(Ⅱ′-3)所代表的化合物；(C)将式(Ⅱ-3)或(Ⅱ′-3)化合物分别与下式(Ⅱ-4)或(Ⅱ′-4)代表的化合物进行反应，分别得到下式(Ⅱ-5)和(Ⅱ′-5)代表的化合物；(D)用式(III)催化剂对式(II-5)或(II′-5)化合物进行环化反应，分别得到下式(I)或(I′)代表的化合物。式(Ⅰ)、(Ⅰ′)、(Ⅱ-1)至(Ⅱ-5)、(Ⅱ′-1)至(Ⅱ′-5)和(Ⅲ)如说明书所示。
• CYCLOPEPTIDE, PHARMACEUTICAL OR COSMETIC COMPOSITION COMPRISING THE SAME AND METHOD FOR PREPARING THE SAME
  申请人：National Tsing Hua University

  公开号：EP3392262B1

  公开（公告）日：2021-08-18
• METHOD FOR PREPARING A CYCLOPEPTIDE
  申请人：National Tsing Hua University

  公开号：EP3628677B1

  公开（公告）日：2021-11-10
• METHOD FOR PREPARING CYCLOPEPTIDE
  申请人：National Tsing Hua University

  公开号：US20200339632A1

  公开（公告）日：2020-10-29

  A method for preparing a cyclopeptide, which includes the following steps: (A) providing compounds represented by the following formulas (II-1) or (II′-1) and (II-2); (B) performing a reaction between the compounds of formulas (II-1) or (II′-1) and (II-2), to obtain a compound represented by the following formula (II-3) and (II′-3), respectively; (C) performing a reaction between the compound of formula (II-3) or (II′-3) and a compound represented by the following formula (II-4) or (II′-4), respectively, is performed, to obtain a compound represented by the following formula (II-5), and (II′-5), respectively; (D) performing a cyclization reaction of the compound of formula (II-5) or (II′-5) with a catalyst of formula (III), to obtain a compound represented by the following formula (I) or (I′), respectively. The formulas (I), (I′), (II-1) to (II-5), (II′-1) to (II′-5) and (III) are shown in the specification.
• Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same
  申请人：National Tsing Hua University

  公开号：US20180298060A1

  公开（公告）日：2018-10-18

  A cyclopeptide is disclosed, which is represented by the following formula (I) or (I′): wherein R 1 is defined in the specification. In addition, a pharmaceutical or cosmetic composition comprising the same and a method for preparing the same are also disclosed.

  本发明揭示了一种环肽，其由以下式子(I)或(I')表示：其中R1在规范中有定义。此外，还揭示了包含该环肽的药物或化妆品组合物以及制备该组合物的方法。