13-methyl-7,8,9,14-tetrahydroquinolino[2',3':7,6]cyclohept[1,2-b]indole-6-carboxylic acid | 1357598-49-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 13-methyl-7,8,9,14-tetrahydroquinolino[2',3':7,6]cyclohept[1,2-b]indole-6-carboxylic acid
• 英文别名: 5-Methyl-3,22-diazapentacyclo[12.8.0.02,10.04,9.016,21]docosa-1(22),2(10),4,6,8,14,16,18,20-nonaene-15-carboxylic acid
• CAS: 1357598-49-2
• 化学式: C₂₂H₁₈N₂O₂
• 分子量: 342.397
• InChiKey: DDVRICARWLZBHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  66
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  靛红 、 9-methyl-1-oxo-1,2,3,4,5,10-hexahydrocyclohept[b]indole 在 水 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以80%的产率得到13-methyl-7,8,9,14-tetrahydroquinolino[2',3':7,6]cyclohept[1,2-b]indole-6-carboxylic acid
  参考文献：
  名称：

  Elegant One-Pot Synthesis of Quinolino[2′,3′:7,6]-cyclohept[1,2-b]indole Through Friedländer and Pfitzinger Annulation Reaction

  摘要：

  A rapid, simple, and efficient method for the preparation of various quinolino[2',3': 7,6] cyclohept[1,2-b]indoles has been developed through the Friedlander and Pfitzinger condensations of 1-oxo-cyclohept[b]indole with o-amino benzophenone and isatin respectively. Reactions were performed by under different reaction conditions.

  DOI：

  10.1080/00397911.2010.518048

文献信息

• Elegant One-Pot Synthesis of Quinolino[2′,3′:7,6]-cyclohept[1,2-<i>b</i>]indole Through Friedländer and Pfitzinger Annulation Reaction
  作者：Ezhumalai Yamuna、Anthony Yurcho、Robert J. Sovesky、Peter M. Smith、Matthias Zeller、Karnam Jayarampillai Rajendra Prasad

  DOI：10.1080/00397911.2010.518048

  日期：2011.11.15

  A rapid, simple, and efficient method for the preparation of various quinolino[2',3': 7,6] cyclohept[1,2-b]indoles has been developed through the Friedlander and Pfitzinger condensations of 1-oxo-cyclohept[b]indole with o-amino benzophenone and isatin respectively. Reactions were performed by under different reaction conditions.