N-[(5-chloro-8-hydroxyquinolin-7-yl)-(furan-2-yl)methyl]-4-methoxybenzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[(5-chloro-8-hydroxyquinolin-7-yl)-(furan-2-yl)methyl]-4-methoxybenzamide
• 化学式: C₂₂H₁₇ClN₂O₄
• 分子量: 408.8
• InChiKey: RVZSTPJGDWAULM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  84.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] INHIBITORS OF JMJD2C AS ANTICANCER AGENTS<br/>[FR] INHIBITEURS DE JMJD2C UTILISÉS EN TANT QU'AGENTS ANTICANCÉREUX
  申请人：DAVID GLADSTONE INST

  公开号：WO2015167874A1

  公开（公告）日：2015-11-05

  The present disclosure provides compounds, pharmaceutical compositions and related methods for the treatment of cancer, e.g., castration-resistant prostate cancer (CRPC). Specifically, the present disclosure provides a series of 8-hydroxyquinoline derivatives which show cytotoxic effects on androgen-independent prostate cancer cells.

  本公开提供了化合物、制药组合物和相关方法，用于治疗癌症，例如去势抵抗性前列腺癌（CRPC）。具体而言，本公开提供一系列8-羟基喹啉衍生物，其对雄激素非依赖性前列腺癌细胞具有细胞毒性作用。
• INHIBITORS OF JMJD2C AS ANTICANCER AGENTS
  申请人：The J. David Gladstone Institutes

  公开号：EP3137079A1

  公开（公告）日：2017-03-08
• Inhibitors of JMJD2C as Anticancer Agents
  申请人：The J. David Gladstone Institutes

  公开号：US20170044107A1

  公开（公告）日：2017-02-16

  The present disclosure provides compounds, pharmaceutical compositions and related methods for the treatment of cancer, e.g., castration-resistant prostate cancer (CRPC). Specifically, the present disclosure provides a series of 8-hydroxyquinoline derivatives which show cytotoxic effects on androgen-independent prostate cancer cells.