N.N'-Diallyl-oxamid | 22965-63-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N.N'-Diallyl-oxamid
• 英文别名: Oxalsaeure-bis-allylamid；N,N'-diallyl-oxalamide；N,N'-Diallyl-oxalamid；N~1~,N~2~-diallylethanediamide；N,N'-bis(prop-2-enyl)oxamide
• CAS: 22965-63-5
• 化学式: C₈H₁₂N₂O₂
• mdl: MFCD01059339
• 分子量: 168.195
• InChiKey: XSYROVOMEUABKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N.N'-Diallyl-oxamid 在 过氧乙酸 、 氯仿 、 溶剂黄146 作用下， 生成 N,N'-bis-oxiranylmethyl-oxalamide
  参考文献：
  名称：

  Amides of epoxyamines

  摘要：

  公开号：

  US02730531A1
• 作为产物：
  描述：

  草酸二乙酯 、 丙烯胺 生成 N.N'-Diallyl-oxamid
  参考文献：
  名称：

  Kochergin,P.M.; Bushueva,K.S., Journal of applied chemistry of the USSR, 1962, vol. 35, p. 2633 - 2636

  摘要：

  DOI：

文献信息

• γ-Lactam analogues of penicillanic and carbapenicillanic acids
  作者：Jack E. Baldwin、Ming Fai Chan、Gerard Gallacher、Masami Otsuka、Peter Monk、Keith Prout

  DOI：10.1016/s0040-4020(01)98828-3

  日期：——

  (12a) and (12b) in a ratio of 85 : 15. They are transformed to the carbapenam analogues (1)-(4). Their stereochemistry was assigned according to the X-ray structure of the γ-lactam (12b). Benzyl 6-oxopenicillanate (20) was directly transformed to the γ-lactam analogue (5) a novel ring expansion. These synthetic analogues did not show antibiotic activity or β-lactamase inhibition. Treatment of pyrro1idine-2

  描述了青霉素和碳青霉烯酸的γ-内酰胺类似物的合成和生物活性，以及​​高碘酸钠介导的吡咯烷-2,3-二酮的重排。环硝酮（6）和丙烯酸甲酯的1，3-偶极加成得到双环加合物（7a）和（7b）。NO键的还原性切割和随后的区域异构体（11a）的环化以85∶15的比例得到γ-内酰胺（12a）和（12b）。它们被转化为碳青霉烯类似物（1）-（4）。根据γ-内酰胺（12b）的X射线结构确定其立体化学。将苄基6-氧Openicillanate（20）直接转化为γ-内酰胺类似物（5）新颖的戒指扩张。这些合成类似物没有显示抗生素活性或β-内酰胺酶抑制作用。用高碘酸钠处理吡咯烷2，3-二酮（25a）和（25b），分别得到环收缩的β-内酰胺（26a）和（26b）。对（27）进行类似处理，然后再使用重氮甲烷，得到了意想不到的螺环氧化物。
• Method for isolating (R)-tofisopam
  申请人：Vela Pharmaceuticals, Inc.

  公开号：US20040254174A1

  公开（公告）日：2004-12-16

  (R)-tofisopam, substantially free of the (S)-enantiomer of tofisopam, is obtained by separating the enantiomers of tofisopam by chromatography employing a chiral separation medium comprising (i) (2S)-2-{(1S)[(3,5-dinitrophenyl)carbonylamino]phenylmethyl}-3,3-dimethylbutanoate, covalently bound to silica through an alkylene ester linkage or (ii) an amylose derivative of formula I: 1 wherein each R 1 and n are defined herein; the amylose derivative being coated on a porous inorganic carrier or a porous organic carrier.

  (R)-托非索帕姆，基本上不含托非索帕姆的(S)-对映体，是通过利用手性分离介质进行色谱分离托非索帕姆的对映体而得到的，该手性分离介质包括(i) (2S)-2-(1S)-[(3,5-二硝基苯基)羰基氨基]苯甲基}-3,3-二甲基丁酸丁酯，通过烷基酯键结合到硅胶上，或(ii) 公式I:1的一种糖苷衍生物，其中每个R1和n在此定义；该糖苷衍生物被涂覆在多孔无机载体或多孔有机载体上。
• Diazabicyclic Aryl Derivatives as Nicotinic Acetylcholine Receptor Ligands
  申请人：Peters Dan

  公开号：US20080227772A1

  公开（公告）日：2008-09-18

  This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及一种新的二氮杂双环芳基衍生物，发现它们在尼古丁乙酰胆碱受体上具有胆碱能配体的作用。由于其药理特性，本发明中的化合物可能对治疗与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统相关的疾病或疾病，与平滑肌收缩相关的疾病或疾病，内分泌疾病或疾病，与神经退行性相关的疾病或疾病，与炎症、疼痛以及由于化学物质滥用终止引起的戒断症状等各种疾病或疾病可能有用。
• Polymers of self- and hydroxyl reactive formaldehyde-free cyclic hemiamidal and hemiamide ketal crosslinking monomers
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0211432A2

  公开（公告）日：1987-02-25

  A compound represented by the following formula: wherein R is a C3-C21 olefinically unsaturated organic radical having functionality which renders the nitrogen atom electron deficient, the olefinic unsaturation functionality being polymerizable, R' is hydrogen or a C1-C4 alkyl radical, or R and R' together with the nitrogen atom can form an olefinically unsaturated 5 to 7-member ring which has functionality that renders the nitrogen atom electron deficient and the olefinic unsaturation functionality is polymerizable, R2 and R3 are hydrogen, a C1-C4 alkyl or acyl radical, or R2 and R3 together are a C2-C4 alkylene group, R4 is hydrogen or a C1-C4 alkyl, acyl, ester, amide or acid group, and n is an integer from 1 to 10, provided n is not 1 when R is (meth)acryloyl, R2 and R3 are methyl and R' and R4 are hydrogen. Under acidic conditions the above compounds in which R' is hydrogen afford cyclic hemiamidals and hemiamide ketals of the following formula: The dialkyl acetal and ketal compounds and the cyclic hemiamidal and hemiamide ketal compounds can be homopolymerized or polymerized with other copolymerizable monomers.

  下式所代表的化合物： 其中 R 是 C3-C21 烯烃不饱和有机基，具有使氮原子缺电子的官能度，烯烃不饱和官能度可聚合、 R' 是氢或 C1-C4 烷基，或 R 和 R'与氮原子一起可形成烯烃不饱和 5 至 7 元环，该环具有使氮原子缺电子的官能度，且烯烃不饱和官能度可聚合、 R2 和 R3 是氢、C1-C4 烷基或酰基，或 R2 和 R3 合在一起是一个 C2-C4 烯基、 R4 是氢或 C1-C4 烷基、酰基、酯基、酰胺基或酸基，以及 n 是 1 到 10 的整数，但当 R 是（甲基）丙烯酰基、R2 和 R3 是甲基、R'和 R4 是氢时，n 不是 1。 在酸性条件下，R'为氢的上述化合物可生成下式的环半酰胺和半酰胺酮： 二烷基缩醛和缩酮化合物以及环半酰胺和半酰胺缩酮化合物可以均聚或与其他可共聚单体聚合。
• Polymers of self- and diol reactive formaldehyde-free crosslinking monomers
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0218827A2

  公开（公告）日：1987-04-22

  A compound represented by the following formula: wherein R is a C3-C24 olefinically unsaturated organic radical having functionality which renders the nitrogen atom electron deficient, the olefinic unsaturation functionality being polymerizable. R' is hydrogen or a C,-C4 alkyl radical, or R and R' together with the nitrogen atom can form an olefinically unsaturated 5 7-member ring which has functionality that renders the nitrogen atom electron deficient and the olefinic unsaturation functionality is polymerizable, R2 and R3 are hydrogen, a C1-C4 alkyl or acyl radical, or R2 and R3 together are a C2-C4 alkylene group, R4 is hydrogen or a C,-C4 alkyl, acyl, ester, amide or acid group. and n is an integer from 1 to 10, provided n is not 1 when R is (meth)acryloyl, R2 and R3 are methyl and R' and R4 are hydrogen. Under acidic conditions the above compounds in which R' is hydrogen afford cyclic hemiamidals and hemiamide ketals of the following formula: The dialkyl acetal and ketal compounds and the cyclic hemiamidal and hemiamide ketal compounds can be homopolymerized or polymerized with other copolymerizable monomers.

  下式所代表的化合物： 其中 R 是 C3-C24 烯烃不饱和有机基，具有使氮原子缺电子的官能团，烯烃不饱和官能团可聚合。 R' 是氢或 C，-C4 烷基，或 R 和 R'与氮原子一起可形成一个烯烃不饱和 5-7 元环，该环具有使氮原子缺电子的官能度，且烯烃不饱和官能度可聚合、 R2 和 R3 是氢、C1-C4 烷基或酰基，或 R2 和 R3 合在一起是 C2-C4 烯基、 R4 是氢或 C,-C4烷基、酰基、酯基、酰胺基或酸基。 n 是 1 到 10 的整数，但当 R 是（甲基）丙烯酰基，R2 和 R3 是甲基，R'和 R4 是氢时，n 不是 1。 在酸性条件下，R'为氢的上述化合物可生成下式的环半酰胺和半酰胺酮： 二烷基缩醛和缩酮化合物以及环半酰胺和半酰胺缩酮化合物可以均聚或与其他可共聚单体聚合。