N-((5-chloro-8-hydroxyquinolin-7-yl)(p-tolyl)methyl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-((5-chloro-8-hydroxyquinolin-7-yl)(p-tolyl)methyl)acetamide
• 英文别名: N-[(5-chloro-8-hydroxyquinolin-7-yl)(4-methylphenyl)methyl]acetamide；N-[(5-Chloro-8-hydroxy-quinolin-7-yl)-p-tolyl-methyl]-acetamide；N-[(5-chloro-8-hydroxyquinolin-7-yl)-(4-methylphenyl)methyl]acetamide
• 化学式: C₁₉H₁₇ClN₂O₂
• 分子量: 340.809
• InChiKey: NTUQQFGFRQITLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• GLYCOSAMINOGLYCAN INHIBITORS
  申请人：Crawford Brett E.

  公开号：US20120295890A1

  公开（公告）日：2012-11-22

  Provided herein are chondroitin sulfate inhibitors, including modulators of glycosylation, and/or sulfation of galactose or N-acetyl galactosamine glycosaminoglycans.
• [EN] GLYCOSAMINOGLYCAN INHIBITORS<br/>[FR] INHIBITEURS DE GLYCOSAMINOGLYCANE
  申请人：ZACHARON PHARMACEUTICALS INC

  公开号：WO2011082175A2

  公开（公告）日：2011-07-07

  Provided herein are chondroitin sulfate inhibitors, including modulators of glycosylation, and/or sulfation of galactose or N-acetyl galactosamine glycosaminoglycans.
• [EN] SUBSTITUTED N-BENZHYDRYLACETAMIDE INHIBITORS OF JUMANJI DOMAIN HISTONE DEMETHYLASES FOR THE TREATMENT OF CANCER<br/>[FR] INHIBITEURS N-BENZHYDRYLACÉTAMIDE SUBSTITUÉS D'HISTONE DÉMÉTHYLASES À DOMAINE JUMANJI POUR LE TRAITEMENT DU CANCER
  申请人：UNIV KENTUCKY RES FOUND

  公开号：WO2021178721A1

  公开（公告）日：2021-09-10

  Provided herein are compounds for inhibiting Wnt signaling and methods of treating cancer. The compounds include any compound having a structure according to Formula II. The method includes administering one or more compounds according to Formula I and/or Formula II to a subject in need thereof.