N-[(2,4-dichlorophenyl)(8-hydroxyquinolin-7-yl)methyl]-3-methylbutanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[(2,4-dichlorophenyl)(8-hydroxyquinolin-7-yl)methyl]-3-methylbutanamide
• 英文别名: N-[(2,4-dichlorophenyl)-(8-hydroxy-7-quinolyl)methyl]-3-methyl-butanamide；N-[(2,4-dichlorophenyl)-(8-hydroxyquinolin-7-yl)methyl]-3-methylbutanamide
• 化学式: C₂₁H₂₀Cl₂N₂O₂
• 分子量: 403.308
• InChiKey: RYNCRISZMOBICO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• QUINOLINE DERIVATIVES
  申请人：Envivo Pharmaceuticals, Inc.

  公开号：EP2079699A1

  公开（公告）日：2009-07-22
• GLYCOSAMINOGLYCAN INHIBITORS
  申请人：Crawford Brett E.

  公开号：US20120295890A1

  公开（公告）日：2012-11-22

  Provided herein are chondroitin sulfate inhibitors, including modulators of glycosylation, and/or sulfation of galactose or N-acetyl galactosamine glycosaminoglycans.
• [EN] QUINOLINE DERIVATIVES<br/>[FR] DÉRIVÉS DE QUINOLINE
  申请人：CHRONOGEN INC

  公开号：WO2008014602A1

  公开（公告）日：2008-02-07

  [EN] The invention relates to new quinoline derivatives which are active CLK-1 inhibitors. More specifically, the CLK-1 inhibitors of the invention are compounds of formula (A). The invention also relates to pharmaceutical compositions comprising such compounds and to methods for the prophylaxis and/or treatment of disorders or their associated symptoms for which the inhibition of CLK-1 is beneficial.
  [FR] L'invention concerne de nouveaux dérivés de quinoline constituant des inhibiteurs actifs de CLK-1. Les inhibiteurs de CLK-1 de l'invention sont, plus spécifiquement, des composés représentés par la formule (A). L'invention concerne également des compositions pharmaceutiques contenant lesdits composés et des méthodes prophylactiques et/ou thérapeutiques de troubles ou des symptômes associés dans lesquels l'inhibition de CLK-1 est bénéfique.
• [EN] METHODS OF TREATMENT USING WNT INHIBITORS<br/>[FR] PROCÉDÉS DE TRAITEMENT UTILISANT DES INHIBITEURS DE WNT
  申请人：UNIV UTAH RES FOUND

  公开号：WO2010014948A1

  公开（公告）日：2010-02-04

  Described herein are methods of treating a cancer mediated by a Wnt signaling pathway, with a variety of compounds, including Wnt inhibitor compounds. Also described are methods of identifying compounds capable of modulating a Wnt signaling pathway.