(2S)-2-[(1-oxo-10H-acridin-2-yl)amino]propanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (2S)-2-[(1-oxo-10H-acridin-2-yl)amino]propanoic acid
• 化学式: C₁₆H₁₄N₂O₃
• 分子量: 282.29
• InChiKey: PKAQTJTXKDKVBS-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Azetidine-substituted fluorescent compounds
  申请人：HOWARD HUGHES MEDICAL INSTITUTE

  公开号：US10018624B1

  公开（公告）日：2018-07-10

  The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.

  本公开的主题包括氮杂环丁烷取代的荧光化合物，这些化合物可用作探针、染料、标签等。本公开主题还包括包含上述化合物的试剂盒以及使用上述化合物检测目标物质的方法。
• AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS
  申请人：Howard Hughes Medical Institute

  公开号：EP3126451B1

  公开（公告）日：2020-09-09
• US9933417B2
  申请人：——

  公开号：US9933417B2

  公开（公告）日：2018-04-03
• [EN] PROTEIN KINASE ALLOSTERY SENSOR AND METHODS OF MAKING AND USING SAME<br/>[FR] CAPTEUR D'ALLOSTÉRIE DE PROTÉINE KINASE ET PROCÉDÉS POUR SA PRODUCTION ET SON UTILISATION
  申请人：UNIV MINNESOTA

  公开号：WO2018049112A1

  公开（公告）日：2018-03-15

  A protein kinase that includes a donor molecule and an acceptor molecule, methods of making the protein kinase, and methods of using the protein kinase are described. Measurement of the conformation of the kinase can be obtained using intramolecular FRET. The protein kinase can be used to, for example, identify conformational changes involved in kinase regulation, that is, as an allostery sensor; to identify kinase-binding molecules including, for example, kinase inhibitors; to identify cancer therapeutics; or for high-throughput screening.