5,6,7-trimethoxy-4-[3-(trifluoromethyl)phenyl]-3,4-dihydroquinolin-2(1H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5,6,7-trimethoxy-4-[3-(trifluoromethyl)phenyl]-3,4-dihydroquinolin-2(1H)-one
• 英文别名: 5,6,7-trimethoxy-4-[3-(trifluoromethyl)phenyl]-3,4-dihydro-1H-quinolin-2-one
• 化学式: C₁₉H₁₈F₃NO₄
• 分子量: 381.3
• InChiKey: AFVFRDCVBPIBPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• COMBINATION THERAPIES FOR TREATMENT OF SPINAL MUSCULAR ATROPHY
  申请人：Indiana University Research and Technology Corporation

  公开号：US20170239225A1

  公开（公告）日：2017-08-24

  Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.

  本文揭示了治疗脊髓性肌萎缩症（SMA）的组合物和方法。在某些实施例中，提供了一些化合物，可以通过SMN2基因增加全长生存运动神经元（SMN）蛋白的产生。
• Combination therapies for treatment of spinal muscular atrophy
  申请人：Indiana University Research and Technology Corporation

  公开号：US10420753B2

  公开（公告）日：2019-09-24

  Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.

  本文公开了用于治疗脊髓性肌萎缩症（SMA）的组合物和方法。在某些实施方案中，所提供的化合物可增加由 SMN2 基因产生的运动神经元（SMN）全长存活蛋白。
• SCREENING METHODS FOR SPINAL MUSCULAR ATROPHY
  申请人：Indiana University Research and Technology Corporation

  公开号：US20140193906A1

  公开（公告）日：2014-07-10

  Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.
• COMPOUNDS FOR USE IN SCREENING METHODS FOR SPINAL MUSCULAR ATROPHY
  申请人：Indiana University Research and Technology Corporation

  公开号：US20160052935A1

  公开（公告）日：2016-02-25

  Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.
• US9212209B2
  申请人：——

  公开号：US9212209B2

  公开（公告）日：2015-12-15