4,4'-ethanediyl-bis-cyclohexanol | 29917-39-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,4'-ethanediyl-bis-cyclohexanol
• 英文别名: 4,4'-Aethandiyl-bis-cyclohexanol；4-[2-(4-Hydroxycyclohexyl)ethyl]cyclohexan-1-ol
• CAS: 29917-39-3
• 化学式: C₁₄H₂₆O₂
• 分子量: 226.359
• InChiKey: IYVQJILIWOLAFZ-UHFFFAOYSA-N

物化性质

• 熔点：
  142.5-143.3 °C(Solv: ethyl acetate (141-78-6))
• 沸点：
  362.8±10.0 °C(Predicted)
• 密度：
  1.026±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,4'-ethanediyl-bis-cyclohexanol 在 sodium dichromate 、 溶剂黄146 、 苯 作用下， 生成 4,4'-ethanediyl-bis-cyclohexanone
  参考文献：
  名称：

  1,2-二-（4-酮环己烷）-乙烷。

  摘要：

  DOI：

  10.1021/ja01190a604
• 作为产物：
  描述：

  trans-4,4'-dihydroxystilbene 在 甲醇 、 镍 作用下， 220.0 ℃ 、29.42 MPa 条件下， 生成 4,4'-ethanediyl-bis-cyclohexanol 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  1,2-二-（4-酮环己烷）-乙烷。

  摘要：

  DOI：

  10.1021/ja01190a604

文献信息

• Molecular classification of psoriasis disease-associated genes through pharmacogenomic expression profiling
  作者：J L Oestreicher、I B Walters、T Kikuchi、P Gilleaudeau、J Surette、U Schwertschlag、A J Dorner、J G Krueger、W L Trepicchio

  DOI：10.1038/sj.tpj.6500067

  日期：2001.4

  Psoriasis is recognized as the most common T cell-mediated inflammatory disease in humans. Genetic linkage to as many as six distinct disease loci has been established but the molecular etiology and genetics remain unknown. To begin to identify psoriasis disease-related genes and construct in vivo pathways of the inflammatory process, a genome-wide expression screen of multiple psoriasis patients was undertaken. A comprehensive list of 159 genes that define psoriasis in molecular terms was generated; numerous genes in this set mapped to six different disease-associated loci. To further interpret the functional role of this gene set in the disease process, a longitudinal pharmacogenomic study was initiated to understand how expression levels of these transcripts are altered following patient treatment with therapeutic agents that antagonize calcineurin or NF-κB pathways. Transcript levels for a subset of these 159 genes changed significantly in those patients who responded to therapy and many of the changes preceded clinical improvement. The disease-related gene map provides new insights into the pathogenesis of psoriasis, wound healing and cellular-immune reactions occurring in human skin as well as other T cell-mediated autoimmune diseases. In addition, it provides a set of candidate genes that may serve as novel therapeutic intervention points as well as surrogate and predictive markers of treatment outcome.

  银屑病被认为是人类最常见的由 T 细胞介导的炎症性疾病。多达六个不同疾病基因位点的遗传联系已经确定，但分子病因学和遗传学仍然未知。为了开始确定银屑病疾病相关基因并构建炎症过程的体内通路，对多名银屑病患者进行了全基因组表达筛选。结果得出了一份包含 159 个可从分子角度定义银屑病的基因的综合列表；该列表中的许多基因都与六个不同的疾病相关基因位点相对应。为了进一步解释这组基因在疾病过程中的功能作用，我们启动了一项纵向药物基因组学研究，以了解患者在接受拮抗钙神经蛋白或 NF-κB 通路的治疗药物治疗后，这些转录物的表达水平会发生怎样的变化。在对治疗有反应的患者中，这 159 个基因子集的转录本水平发生了显著变化，而且许多变化发生在临床症状改善之前。与疾病相关的基因图谱为银屑病的发病机制、伤口愈合、人类皮肤发生的细胞免疫反应以及其他T细胞介导的自身免疫性疾病提供了新的见解。此外，它还提供了一组候选基因，可作为新的治疗干预点以及治疗结果的替代和预测标记。
• HEAT-AGING-RESISTANT POLYAMIDES
  申请人：Prusty Manoranjan

  公开号：US20120010343A1

  公开（公告）日：2012-01-12

  Thermoplastic molding compositions, comprising A) from 10 to 99.99% by weight of a polyamide B) from 0.01 to 20% by weight of a high-functionality polyetherol with an OH number of from 3 to 1350 mg KOH/g of polyetherol (to DIN 53240, part 2), C) from 0 to 70% by weight of further additives, where the total of the percentages by weight of components A) to C) is 100%.

  热塑性模塑组合物，包括A）10至99.99重量％的聚酰胺B）0.01至20重量％的具有3至1350毫克KOH /聚醚醇的高功能聚醚醇（根据DIN 53240第2部分计算），C）0至70重量％的进一步添加剂，其中组分A）至C）的重量百分比之和为100％。
• Curable epoxy resin composition
  申请人：ASAHI DENKA KOGYO KABUSHIKI KAISHA

  公开号：EP0197458A2

  公开（公告）日：1986-10-15

  A thermosetting epoxy resin composition of one pack type is provided which contains as indispensable constituents (I) an epoxy resin containing more than one adjacent epoxy groups on the average in the molecule and (II) curing amount or curing-accelerating amount of a compound obtained by reacting (a) a specified amine/epoxy adduct with (b) phenolic , resin(s) and/or polyhydric phenol compound(s) in a weight ratio of (a) to (b) of 1/0.1 to 1/0.8. The composition of the present invention has excellent storage stability and it is curable at a relatively low temperature to form a cured product having excellent mechanical strength, adhesiveness and water resistance.

  本发明提供了一种单组分热固性环氧树脂组合物，其不可或缺的成分包括：(I) 分子中平均含有一个以上相邻环氧基团的环氧树脂；(II) 固化量或固化加速量的化合物，该化合物由(a)特定的胺/环氧加合物与(b)酚醛树脂和/或多羟基酚化合物反应而得，(a)与(b)的重量比为 1/0.1 至 1/0.8。本发明的组合物具有极佳的储存稳定性，可在相对较低的温度下固化，形成具有极佳机械强度、粘合性和耐水性的固化产品。
• Thermoplastic polyurethanes with high glass transition temperatures
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0320946A2

  公开（公告）日：1989-06-21

  Disclosed are novel high flexural modulus polyurethane plastics wherein a polyisocyanate and a particular combination of extenders including cycloalkane diol are reacted optionally in the presence of a minor proportion of high molecular weight polyol. The polymers have outstanding resistance to high temperatures thereby expanding their utilities into higher temperature end-use environments than related prior art materials. Certain members of these new polymers are also possessed of outstanding optical clarity which thereby provides a combination of properties heretofore not available in a polyurethane. These polymers are easily melt-fabricated notwithstanding their inherent high temperature properties.

  本发明公开了新型高弯曲模量聚氨酯塑料，在这种塑料中，多异氰酸酯和包括环烷二 醇在内的特定扩展剂组合在少量高分子量多元醇的存在下发生反应。 这种聚合物具有出色的耐高温性能，因此，与相关的现有技术材料相比，它们可以在更高温度的最终使用环境中使用。这些新型聚合物的某些成分还具有出色的光学清晰度，从而提供了迄今为止聚氨酯所不具备的综合特性。尽管这些聚合物具有固有的高温特性，但它们易于熔融制造。
• Optical thermoplastic thiourethane-urethane copolymers
  申请人：Optima Inc.

  公开号：EP0780413A1

  公开（公告）日：1997-06-25

  A process for making the thermoplastic thiourethane-urethane copolymers for use in making optical products comprising forming e.g. a thiourethane prepolymer, preferably by reaction of an aliphatic diisocyanate with a dithiol, and then reacting the prepolymer with a polyurethane-forming monomer which is preferably the combination of a diisocyanate such as methylene bis(phenyl isocyanate) and a polyol such as a diaromatic containing diol such as ethoxylated Bisphenol A or an aliphatic isocyanate reactive monomer such as tricyclodecane dimethanol or 1,4-dimethanol cyclohexane, to form the copolymer product. The polymers have a combination of high refractive index and high Abbe No. The polymers also have high impact strength, high hardness and Tg's above 100°C. It is preferred to make the polymer in an extruder.

  一种用于制造光学产品的热塑性硫代氨基甲酸酯-氨基甲酸乙酯共聚物的生产工艺，包括以下步骤硫代氨基甲酸酯预聚物，最好是通过脂肪族二异氰酸酯与二硫醇的反应、然后将预聚物与聚氨酯形成单体反应，聚氨酯形成单体最好是二异氰酸酯（如亚甲基双（苯基异氰酸酯））和多元醇（如含二芳香族的二元醇，如乙氧基化双酚 A）或脂肪族异氰酸酯反应单体（如三环十二烷二甲醇或 1,4-二甲醇环己烷）的组合，以形成共聚物产品。这种聚合物兼具高折射率和高阿贝数，还具有高冲击强度、高硬度和高于 100°C 的 Tg。最好用挤压机制造聚合物。