2,2-trans-4,6-Tetramethyl-1,3-dioxan | 578763-80-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-trans-4,6-Tetramethyl-1,3-dioxan
• 英文别名: trans-2,2,4,6-Tetramethyl-1,3-dioxane；(4R,6R)-2,2,4,6-tetramethyl-1,3-dioxane
• CAS: 578763-80-1
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: GPKRWHGIASNHBE-RNFRBKRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-trans-4,6-Tetramethyl-1,3-dioxan 在 2,3,5-三甲基吡啶 、 tri-tert-butoxysilanethiol 作用下， 以 正辛烷 为溶剂， 反应 1.0h， 生成 cis-2,2,4,6-tetramethyl-1,3-dioxane
  参考文献：
  名称：

  Selective radical-chain epimerisation at CH centres α to oxygen under conditions of polarity-reversal catalysis

  摘要：

  Polarity-reversal catalysis by tri-tert-butoxysilanethiol has been applied to promote radical-chain epimerisation selectively at carbon centres of the type (RRC)-R-1-C-2*(H)OR. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00704-2
• 作为产物：
  描述：

  cis-2,2,4,6-tetramethyl-1,3-dioxane 在 2,3,5-三甲基吡啶 、 tri-tert-butoxysilanethiol 作用下， 以 正辛烷 为溶剂， 反应 1.0h， 生成 2,2-trans-4,6-Tetramethyl-1,3-dioxan
  参考文献：
  名称：

  Selective radical-chain epimerisation at CH centres α to oxygen under conditions of polarity-reversal catalysis

  摘要：

  Polarity-reversal catalysis by tri-tert-butoxysilanethiol has been applied to promote radical-chain epimerisation selectively at carbon centres of the type (RRC)-R-1-C-2*(H)OR. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00704-2

文献信息

• Chiral and flexible 2,4-pentanediol-tethered cyclopropanation of olefins with a carbenoid derived from a diazo ester to construct three stereogenic centers
  作者：Takashi Sugimura、Atsushi Mori、Akira Tai、Takahiro Tei、Yasuhiro Sakamoto、Tadashi Okuyama

  DOI：10.1016/s0957-4166(03)00034-x

  日期：2003.4

  2,4-Pentanediol-tethered cyclopropanation of an olefin with an internal carbenoid generated from a diazo ester proceeded smoothly to give a chiral adduct having three stereogenic centers under full stereocontrol. The high stereoselectivity was not affected by the structure of the olefinic portion, studied so far with six substrates. Conversion of the product cyclopropane to other optically active compounds

  烯烃与由重氮酯生成的内部类胡萝卜素的2，4-戊二醇连接的环丙烷化反应平稳进行，得到在完全立体控制下具有三个立体中心的手性加合物。迄今为止，对六种底物的研究都表明，高立体选择性不受烯烃部分结构的影响。还报道了产物环丙烷向其他旋光化合物的转化。
• CYCLOPENTYLPYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS
  申请人：Janssen Pharmaceutica NV

  公开号：US20140051660A1

  公开（公告）日：2014-02-20

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein R 1 , R 2 , R 3 , Q, and G are defined herein.
• US8853418B2
  申请人：——

  公开号：US8853418B2

  公开（公告）日：2014-10-07
• Selective radical-chain epimerisation at CH centres α to oxygen under conditions of polarity-reversal catalysis
  作者：Hai-Shan Dang、Brian P Roberts

  DOI：10.1016/s0040-4039(99)00704-2

  日期：1999.5

  Polarity-reversal catalysis by tri-tert-butoxysilanethiol has been applied to promote radical-chain epimerisation selectively at carbon centres of the type (RRC)-R-1-C-2*(H)OR. (C) 1999 Elsevier Science Ltd. All rights reserved.