3-benzoyl-4-hydroxy-6-methyl-2-quinolone | 90182-02-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-benzoyl-4-hydroxy-6-methyl-2-quinolone
• 英文别名: 3-Benzoyl-4-hydroxy-6-methyl-2(1H)-quinolinone；3-benzoyl-4-hydroxy-6-methyl-1H-quinolin-2-one
• CAS: 90182-02-8
• 化学式: C₁₇H₁₃NO₃
• 分子量: 279.295
• InChiKey: CTPIZNGLUNPINZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 2-Quinolone derivatives
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0101330A2

  公开（公告）日：1984-02-22

  The invention relates to 2-quinolone derivatives represented by the following formula and salts thereof as well as manufacture methods therefor and pharmaceuticals consisting of one or more of said compounds as main ingredients wherein R1, R2, R3, R4 and R5 are same or different and are hydrogen, straight or branched lower alkyl with one to eight chain length, halogen, straight or branched lower alkoxy with one to five chain length, nitro, cyano, straight or branched halogeno lower alkyl with one to three chain length or COOR6 where R6 is hydrogen or straight or branched lower alkyl with one to three chain length, excluding the case where all of R1, R2, R3, R4 and R5 are hydrogen.

  本发明涉及下式所代表的 2-喹啉酮衍生物及其盐，以及其制造方法和以一种或多种上述化合物为主要成分的药物 其中R1、R2、R3、R4和R5相同或不同，且为氢、链长为一至八的直链或支链低级烷基、卤素、链长为一至五的直链或支链低级烷氧基、硝基、氰基、链长为一至三的直链或支链卤代低级烷基或COOR6，其中R6为氢或链长为一至三的直链或支链低级烷基，不包括R1、R2、R3、R4和R5全部为氢的情况。
• US4526894A
  申请人：——

  公开号：US4526894A

  公开（公告）日：1985-07-02