6-氯-3-亚氨基-2,3-二氢哒嗪-2-乙酸 | 127566-18-1

• 物质功能分类: 医药中间体 - 哒嗪类化合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 6-氯-3-亚氨基-2,3-二氢哒嗪-2-乙酸
• 中文别名: 6-氯-3-亚氨基-2,3-二氢吡嗪-2-乙酸
• 英文名称: 3-imino-6-chloro-2,3-dihydropyridazine-2-acetic acid
• 英文别名: 3-imino-6-chloro-2,3-dihydropyridazin-2-acetic acid；2-(6-amino-3-chloropyridazin-1-ium-1-yl)acetate
• CAS: 127566-18-1
• 化学式: C₆H₆ClN₃O₂
• 分子量: 187.586
• InChiKey: KYALFIKYRHGFQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  76.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-氯-3-亚氨基-2,3-二氢哒嗪-2-乙酸 在 5-乙基-2-甲基-吡啶 、 三氯氧磷 作用下， 反应 6.0h， 以0.4%的产率得到2,6-二氯咪唑并[1,2-b]吡嗪
  参考文献：
  名称：

  METHOD FOR PRODUCING IMIDAZO[1,2-b]PYRIDAZINE COMPOUND

  摘要：

  公开号：

  EP1930331B1
• 作为产物：
  描述：

  3-氨基-6-氯哒嗪 在 三乙胺 作用下， 以 甲醇 、 水 为溶剂， 反应 40.5h， 以78%的产率得到6-氯-3-亚氨基-2,3-二氢哒嗪-2-乙酸
  参考文献：
  名称：

  WO2007/26624

  摘要：

  公开号：

文献信息

• METHOD FOR PRODUCING 2,3-DIHYDROPYRIDAZINE COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1932835A1

  公开（公告）日：2008-06-18

  A process for producing a 2,3-dihydropyridazine compound represented by the formula (2): wherein R1, R2 and R3 are the same or different and each represents a hydrogen atom, a halogen atom, an alkyl group which may be substituted with a halogen atom or atoms, an alkenyl group which may be substituted with a halogen atom or atoms, an alkoxy group which may be substituted with a halogen atom or atoms, an alkylthio group, an alkylsulfenyl group, an alkylsulfonyl group or a dialkylamino group; which comprises reacting a salt consisting of bromoacetic acid and an amine compound with a pyridazine compound represented by the formula (1): wherein R1, R2 and R3 are the same meanings as defined above.

  一种生产由式（2）表示的 2,3-二氢哒嗪化合物的工艺： 其中 R1、R2 和 R3 相同或不同，且各自代表氢原子、卤素原子、可被一个或多个卤素原子取代的烷基、可被一个或多个卤素原子取代的烯基、可被一个或多个卤素原子取代的烷氧基、烷硫基、烷基亚磺酰基、烷基磺酰基或二烷基氨基；该工艺包括使由溴乙酸和胺化合物组成的盐与式 (1) 所代表的哒嗪化合物反应： 其中 R1、R2 和 R3 的含义与上述定义相同。
• WO2007/26623
  申请人：——

  公开号：——

  公开（公告）日：——
• LABA, V. I.;SVIRIDOVA, A. V.;LITVINOV, V. P., TEZ. DOKL. 4 BCEC. KONF. XZHMIYA, FARMAKOL. I MEXANIZMY DEJSTVIYA PROTIVO+
  作者：LABA, V. I.、SVIRIDOVA, A. V.、LITVINOV, V. P.

  DOI：——

  日期：——
• PROCESS FOR PRODUCING 2,3-DIHYDROPYRIDAZINE COMPOUND
  申请人：Sasaki Kazuaki

  公开号：US20090105475A1

  公开（公告）日：2009-04-23

  A process for producing a 2,3-dihydropyridazine compound represented by the formula (2): wherein R 1 , R 2 and R 3 are the same or different and each represents a hydrogen atom, a halogen atom, an alkyl group which may be substituted with a halogen atom or atoms, an alkenyl group which may be substituted with a halogen atom or atoms, an alkoxy group which may be substituted with a halogen atom or atoms, an alkylthio group, an alkylsulfenyl group, an alkylsulfonyl group or a dialkylamino group; which comprises reacting a salt consisting of bromoacetic acid and an amine compound with a pyridazine compound represented by the formula (1): wherein R 1 , R 2 and R 3 are the same meanings as defined above.
• PROCESS FOR PRODUCING IMIDAZO[1,2-b]PYRIDAZINE COMPOUND
  申请人：Komoto Ichiro

  公开号：US20100234597A1

  公开（公告）日：2010-09-16

  A process for producing an imidazo[1,2-b]pyridazine compound represented by the formula (2): wherein R 1 , R 2 and R 3 are the same or different and each represents a hydrogen atom, a halogen atom, an alkyl group which may be substituted with a halogen atom or atoms, an alkenyl group which may be substituted with a halogen atom or atoms, or an alkoxy group which may be substituted with a halogen atom or atoms, which comprises reacting a 2,3-dihydropyridazine compound represented by the formula (1): wherein R 1 , R 2 and R 3 are the same meanings as defined above, with a phosphorus oxyhalide in the presence of an organic base which is in an amount of 0.5 mole or more relative to 1 mole of the 2,3-dihydropyridazine compound and 1 mole or less relative to 1 mole of the phosphorus oxyhalide.