N²,N²,7-trimethylguanosine | 40027-70-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: N²,N²,7-trimethylguanosine
• 英文别名: N(2),N(2),7-Trimethylguanosine；9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(dimethylamino)-7-methyl-1H-purin-9-ium-6-one
• CAS: 40027-70-1
• 化学式: C₁₃H₂₀N₅O₅
• 分子量: 326.332
• InChiKey: IYYIBFCJILKPCO-WOUKDFQISA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  123
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N2,N2-二甲基鸟苷 、 硫酸二甲酯 以 N,N-二甲基乙酰胺 为溶剂， 反应 12.0h， 以50%的产率得到N²,N²,7-trimethylguanosine
  参考文献：
  名称：

  Preparation ofN²,N²'7-Trimethylguanosine Affinity Columns

  摘要：

  2,2,7-trimethylguanosine (TMG) binding proteins from human cells were purified through TMG-affinity columns. TMG synthesis was improved and the TMG obtained was shown to be similar to the TMG in the 5' cap of the UsnRNAs. The eluates obtained with TMG-affinity chromatographies were very different from those isolated with m7G-affinity columns, thus suggesting that specific TMG-binding proteins were obtained. The fraction may be enriched with factors associated with import and/or hypermethylation of UsnRNPs.

  DOI：

  10.1080/07328319908045599

文献信息

• Preparation of<i>N</i>²,<i>N</i>²'7-Trimethylguanosine Affinity Columns
  作者：Ruth Espuny、Diana Bahia、Regina Maria Barretto Cicarelli、Caries Codony、Amina Khaouja、Anna Maria Aviñó、Ramon Eritja、Montse Bach-Elias

  DOI：10.1080/07328319908045599

  日期：1999.1

  2,2,7-trimethylguanosine (TMG) binding proteins from human cells were purified through TMG-affinity columns. TMG synthesis was improved and the TMG obtained was shown to be similar to the TMG in the 5' cap of the UsnRNAs. The eluates obtained with TMG-affinity chromatographies were very different from those isolated with m7G-affinity columns, thus suggesting that specific TMG-binding proteins were obtained. The fraction may be enriched with factors associated with import and/or hypermethylation of UsnRNPs.