N-(1,3-dimethylpyrazolo[3,4-b]quinolin-4-yl)-N',N'-dimethylpropane-1,3-diamine;hydron;dichloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(1,3-dimethylpyrazolo[3,4-b]quinolin-4-yl)-N',N'-dimethylpropane-1,3-diamine;hydron;dichloride
• 化学式: C17H25Cl2N5
• 分子量: 370.3
• InChiKey: IFFLDWVHKWYFFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.64
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  46
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Topical application of interferon inducers
  申请人：Merck & Co., Inc.

  公开号：EP0063657A1

  公开（公告）日：1982-11-03

  Virus infections of eye, skin and mucous membrane tissue are effectively treated by controlled-release topical application of interferon inducers. The inducers are included in pharmaceutical compositions with a controlled-release agent such as a pharmaceutically acceptable water-soluble polymer that is solid at body temperature, e.g. a cellulose ether.

  通过局部控释应用干扰素诱导剂，可有效治疗眼部、皮肤和粘膜组织的病毒感染。诱导剂与控释剂（如在体温下为固体的药学上可接受的水溶性聚合物，如纤维素醚）一起包含在药物组合物中。
• Interferon induction method
  申请人：SO "PHARMACHIM"

  公开号：EP0084953A1

  公开（公告）日：1983-08-03

  The kinetics of interferon production in warm blooded animals (humans and mice) with intraperitoneal and oral administration of dipyridamole have shown this substance to possess a high interferon-inducing activity when administered orally at single doses ranging from 12.5 to 100 mg/kg (1/21.5 - 1/172 of the single LD50 value). Peak titres of 2048 - 4096 IU/ml in the blood serum were reached at the 48th hour and elevated interferon levels persisted until the 5th day post inducer administration. Significantly lower interferon titres were found after intraperitoneal injection. Dipyridamole is also effective in in vitro induction of interferon.

  对温血动物（人和小鼠）腹腔和口服双嘧达莫产生干扰素的动力学研究表明，当口服单次剂量为 12.5 至 100 毫克/千克（单次半数致死剂量的 1/21.5 - 1/172）时，这种物质具有很高的干扰素诱导活性。血清中的峰值滴度在第 48 小时达到 2048 - 4096 IU/ml，干扰素水平的升高一直持续到服用诱导剂后的第 5 天。腹腔注射后，干扰素滴度明显降低。双嘧达莫在体外诱导干扰素方面也很有效。
• US4283393A
  申请人：——

  公开号：US4283393A

  公开（公告）日：1981-08-11
• US4499093A
  申请人：——

  公开号：US4499093A

  公开（公告）日：1985-02-12