5-(1,3-Benzodioxol-5-yl)-2,2-dimethyl-1,3,5,6-tetrahydrobenzo[b]phenanthridin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-(1,3-Benzodioxol-5-yl)-2,2-dimethyl-1,3,5,6-tetrahydrobenzo[b]phenanthridin-4-one
• 化学式: C₂₆H₂₃NO₃
• 分子量: 397.5
• InChiKey: BTGXDGANSHWTGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  30
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• MODULATORS OF TDP-43
  申请人：Alteron Therapeutics, Inc.

  公开号：US20220160699A1

  公开（公告）日：2022-05-26

  Provided herein are compositions and methods for reducing toxicity associated with TAR DNA-binding protein 43. Certain embodiments of the present disclosure are related to compositions that treat, inhibit, reduce, prevent, or delay a disease or condition associated with TDP-43 toxicity, such as cystic fibrosis or neurodegenerative diseases. Certain embodiments of the present disclosure are related to methods of treating, inhibiting, reducing, preventing, or delaying a disease or condition associated with TDP-43 toxicity by administering compounds of any one of Formulas (I), (II), (III), (IV), (V), (VI), (VII), or (VIII) to a subject in need.