Methyl 4-(2-isopropoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Methyl 4-(2-isopropoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate
• 英文别名: methyl 2-methyl-5-oxo-4-(2-propan-2-yloxyphenyl)-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
• 化学式: C₂₁H₂₅NO₄
• 分子量: 355.4
• InChiKey: PEIBLUCOYUCRAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION
  申请人：Wang Weidong

  公开号：US20100130476A1

  公开（公告）日：2010-05-27

  The present invention relates to compounds and compositions for inducing the expansion of pancreatic β-cells. The invention further relates to a use of these expanded pancreatic β-cells to reversibly expand pancreatic β-cells and other quiescent cells to overcome deficits associated with degenerative and/or autoimmune diseases.

  本发明涉及用于诱导胰岛素β细胞扩张的化合物和组合物。该发明进一步涉及利用这些扩张的胰岛素β细胞来可逆地扩张胰岛素β细胞和其他静止细胞，以克服与退行性和/或自身免疫疾病相关的缺陷。
• [EN] COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION<br/>[FR] COMPOSÉS QUI INDUISENT L'EXPANSION DE CELLULES BÊTA PANCRÉATIQUES
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2010056907A2

  公开（公告）日：2010-05-20

  The present invention relates to compounds and compositions for inducing the expansion of pancreatic -cells. The invention further relates to a use of these expanded pancreatic -cells to reversibly expand pancreatic -cells and other quiescent cells to overcome deficits associated with degenerative and/or autoimmune diseases.